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XKR5 XK related 5 [ Homo sapiens (human) ]

Gene ID: 389610, updated on 23-Nov-2021

Summary

Official Symbol
XKR5provided by HGNC
Official Full Name
XK related 5provided by HGNC
Primary source
HGNC:HGNC:20782
See related
Ensembl:ENSG00000275591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XRG5A; XRG5BM; UNQ2754; HARL2754
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See XKR5 in Genome Data Viewer
Location:
8p23.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (6808517..6835524, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (6666038..6693046, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5 Neighboring gene Sharpr-MPRA regulatory region 12268 Neighboring gene uncharacterized LOC107986909 Neighboring gene uncharacterized LOC100652791 Neighboring gene defensin beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in apoptotic process involved in development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
XK-related protein 5
Names
X Kell blood group precursor-related family, member 5
X-linked Kx blood group related 5
XK, Kell blood group complex subunit-related family, member 5
XK-related protein 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289973.2NP_001276902.1  XK-related protein 5 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AF233439, AY534242, AY534243
    UniProtKB/Swiss-Prot
    Q6UX68
    Conserved Domains (1) summary
    pfam09815
    Location:3158
    XK-related; XK-related protein
  2. NM_207411.5NP_997294.3  XK-related protein 5 isoform a

    See identical proteins and their annotated locations for NP_997294.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AY534242, AY534243
    Consensus CDS
    CCDS47763.2
    UniProtKB/Swiss-Prot
    Q6UX68
    UniProtKB/TrEMBL
    A0A087X143
    Related
    ENSP00000483879.1, ENST00000618742.3
    Conserved Domains (1) summary
    pfam09815
    Location:5321
    XK-related; XK-related protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    6808517..6835524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013402.1XP_016868891.1  XK-related protein 5 isoform X2

  2. XM_017013401.1XP_016868890.1  XK-related protein 5 isoform X1

  3. XM_011534750.3XP_011533052.1  XK-related protein 5 isoform X3

    Conserved Domains (1) summary
    pfam09815
    Location:1451
    XK-related; XK-related protein

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    203788..230788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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