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FEZF1 FEZ family zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 389549, updated on 23-Nov-2021

Summary

Official Symbol
FEZF1provided by HGNC
Official Full Name
FEZ family zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:22788
See related
Ensembl:ENSG00000128610 MIM:613301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FEZ; HH22; ZNF312B
Summary
This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Restricted expression toward testis (RPKM 1.2) See more
Orthologs
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Genomic context

See FEZF1 in Genome Data Viewer
Location:
7q31.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (122300939..122311855, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (121941357..121944804, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724527 Neighboring gene ribosomal protein L31 pseudogene 37 Neighboring gene VISTA enhancer hs1809 Neighboring gene FEZF1 antisense RNA 1 Neighboring gene calcium dependent secretion activator 2 Neighboring gene uncharacterized LOC105375481

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in cell dedifferentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in olfactory bulb development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
fez family zinc finger protein 1
Names
zinc finger protein 312B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041775.1 RefSeqGene

    Range
    4762..8209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024613.4NP_001019784.2  fez family zinc finger protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001019784.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC015983, AK300742, AY726588, HY206093
    Consensus CDS
    CCDS34741.2
    UniProtKB/Swiss-Prot
    A0PJY2
    Related
    ENSP00000411145.2, ENST00000442488.7
    Conserved Domains (3) summary
    COG5048
    Location:287421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:402420
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001160264.2NP_001153736.1  fez family zinc finger protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001153736.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AY726588, BC127715, DC386457, HY206093
    Consensus CDS
    CCDS55157.1
    UniProtKB/Swiss-Prot
    A0PJY2
    Related
    ENSP00000392727.2, ENST00000427185.2
    Conserved Domains (4) summary
    COG5048
    Location:237371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:352370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255277
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    122300939..122311855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516202.2XP_011514504.1  fez family zinc finger protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011514504.1

    UniProtKB/Swiss-Prot
    A0PJY2
    Conserved Domains (4) summary
    COG5048
    Location:237371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:352370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255277
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005250337.3XP_005250394.1  fez family zinc finger protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005250394.1

    UniProtKB/Swiss-Prot
    A0PJY2
    Conserved Domains (3) summary
    COG5048
    Location:287421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262282
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:402420
    ZF_C2H2; C2H2 Zn finger [structural motif]
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