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ARHGEF37 Rho guanine nucleotide exchange factor 37 [ Homo sapiens (human) ]

Gene ID: 389337, updated on 1-Aug-2020

Summary

Official Symbol
ARHGEF37provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 37provided by HGNC
Primary source
HGNC:HGNC:34430
See related
Ensembl:ENSG00000183111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in skin (RPKM 21.4), prostate (RPKM 12.5) and 20 other tissues See more
Orthologs

Genomic context

See ARHGEF37 in Genome Data Viewer
Location:
5q32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (149552057..149634968)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148961064..149014531)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 145 Neighboring gene casein kinase 1 alpha 1 Neighboring gene ribosomal protein L29 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 10925 Neighboring gene RNA, U6 small nuclear 588, pseudogene Neighboring gene uncharacterized LOC105378224 Neighboring gene RNA, 7SL, cytoplasmic 868, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41603

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 37
Names
Rho guanine nucleotide exchange factor (GEF) 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001669.3NP_001001669.2  rho guanine nucleotide exchange factor 37

    See identical proteins and their annotated locations for NP_001001669.2

    Status: VALIDATED

    Source sequence(s)
    AC021078, AC022100, AK023814, AK123597, BC041325, BF508325, BF510234
    Consensus CDS
    CCDS43385.1
    UniProtKB/Swiss-Prot
    A1IGU5
    Related
    ENSP00000328083.6, ENST00000333677.7
    Conserved Domains (4) summary
    cd07589
    Location:264452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34212
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    149552057..149634968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537642.3XP_011535944.1  rho guanine nucleotide exchange factor 37 isoform X3

    Conserved Domains (4) summary
    cd07589
    Location:275463
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:521574
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:617673
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:45223
    RhoGEF; RhoGEF domain
  2. XM_017009460.1XP_016864949.1  rho guanine nucleotide exchange factor 37 isoform X2

  3. XM_006714784.3XP_006714847.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_006714847.1

    UniProtKB/Swiss-Prot
    A1IGU5
    Conserved Domains (4) summary
    cd07589
    Location:264452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34212
    RhoGEF; RhoGEF domain
  4. XM_017009461.2XP_016864950.1  rho guanine nucleotide exchange factor 37 isoform X5

  5. XM_005268448.1XP_005268505.1  rho guanine nucleotide exchange factor 37 isoform X4

    Conserved Domains (3) summary
    cd07589
    Location:50238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:392448
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
  6. XM_005268447.4XP_005268504.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_005268504.1

    UniProtKB/Swiss-Prot
    A1IGU5
    Conserved Domains (4) summary
    cd07589
    Location:264452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34212
    RhoGEF; RhoGEF domain
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