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ARHGEF37 Rho guanine nucleotide exchange factor 37 [ Homo sapiens (human) ]

Gene ID: 389337, updated on 11-Sep-2019

Summary

Official Symbol
ARHGEF37provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 37provided by HGNC
Primary source
HGNC:HGNC:34430
See related
Ensembl:ENSG00000183111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in skin (RPKM 21.4), prostate (RPKM 12.5) and 20 other tissues See more
Orthologs

Genomic context

See ARHGEF37 in Genome Data Viewer
Location:
5q32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (149552057..149634968)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148961064..149014531)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 145 Neighboring gene casein kinase 1 alpha 1 Neighboring gene ribosomal protein L29 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 10925 Neighboring gene RNA, U6 small nuclear 588, pseudogene Neighboring gene uncharacterized LOC105378224 Neighboring gene RNA, 7SL, cytoplasmic 868, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
    Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
  • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
    NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41603

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 37
Names
Rho guanine nucleotide exchange factor (GEF) 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001669.3NP_001001669.2  rho guanine nucleotide exchange factor 37

    See identical proteins and their annotated locations for NP_001001669.2

    Status: VALIDATED

    Source sequence(s)
    AC021078, AC022100, AK023814, AK123597, BC041325, BF508325, BF510234
    Consensus CDS
    CCDS43385.1
    UniProtKB/Swiss-Prot
    A1IGU5
    Related
    ENSP00000328083.6, ENST00000333677.7
    Conserved Domains (4) summary
    cd07589
    Location:264452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34212
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    149552057..149634968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537642.3XP_011535944.1  rho guanine nucleotide exchange factor 37 isoform X3

    Conserved Domains (4) summary
    cd07589
    Location:275463
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:521574
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:617673
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:45223
    RhoGEF; RhoGEF domain
  2. XM_017009460.1XP_016864949.1  rho guanine nucleotide exchange factor 37 isoform X2

  3. XM_006714784.3XP_006714847.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_006714847.1

    UniProtKB/Swiss-Prot
    A1IGU5
    Conserved Domains (4) summary
    cd07589
    Location:264452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34212
    RhoGEF; RhoGEF domain
  4. XM_017009461.2XP_016864950.1  rho guanine nucleotide exchange factor 37 isoform X5

  5. XM_005268448.1XP_005268505.1  rho guanine nucleotide exchange factor 37 isoform X4

    Conserved Domains (3) summary
    cd07589
    Location:50238
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:296349
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:392448
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
  6. XM_005268447.4XP_005268504.1  rho guanine nucleotide exchange factor 37 isoform X1

    See identical proteins and their annotated locations for XP_005268504.1

    UniProtKB/Swiss-Prot
    A1IGU5
    Conserved Domains (4) summary
    cd07589
    Location:264452
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11799
    Location:510563
    SH3_ARHGEF37_C1; First C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    cd11941
    Location:606662
    SH3_ARHGEF37_C2; Second C-terminal Src homology 3 domain of Rho guanine nucleotide exchange factor 37
    pfam00621
    Location:34212
    RhoGEF; RhoGEF domain
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