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TMPRSS11F transmembrane serine protease 11F [ Homo sapiens (human) ]

Gene ID: 389208, updated on 25-Nov-2021

Summary

Official Symbol
TMPRSS11Fprovided by HGNC
Official Full Name
transmembrane serine protease 11Fprovided by HGNC
Primary source
HGNC:HGNC:29994
See related
Ensembl:ENSG00000198092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HATL4
Expression
Biased expression in esophagus (RPKM 7.7) and skin (RPKM 4.0) See more
Orthologs
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Genomic context

See TMPRSS11F in Genome Data Viewer
Location:
4q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (68053198..68129869, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (68918916..68995587, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene POLR2M pseudogene 1 Neighboring gene MT-ND2 pseudogene 41 Neighboring gene uncharacterized LOC550113 Neighboring gene synaptotagmin 14 pseudogene 1 Neighboring gene solute carrier family 47 member 2 pseudogene Neighboring gene TMPRSS11B N-terminal like, pseudogene Neighboring gene ferritin light chain pseudogene 10 Neighboring gene transmembrane serine protease 11B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16046

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of water loss via skin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protease serine 11F
Names
airway trypsin-like protease 4
transmembrane protease, serine 11F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207407.2NP_997290.2  transmembrane protease serine 11F

    See identical proteins and their annotated locations for NP_997290.2

    Status: VALIDATED

    Source sequence(s)
    AC096727, AK122625, DA441628
    Consensus CDS
    CCDS3520.1
    UniProtKB/Swiss-Prot
    Q6ZWK6
    Related
    ENSP00000348639.2, ENST00000356291.3
    Conserved Domains (3) summary
    smart00020
    Location:205432
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:206435
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:59154
    SEA; SEA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    68053198..68129869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531935.1XP_011530237.1  transmembrane protease serine 11F isoform X1

    Conserved Domains (2) summary
    pfam01390
    Location:59154
    SEA; SEA domain
    cl21584
    Location:206252
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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