U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SMIM20 small integral membrane protein 20 [ Homo sapiens (human) ]

Gene ID: 389203, updated on 26-Oct-2022

Summary

Official Symbol
SMIM20provided by HGNC
Official Full Name
small integral membrane protein 20provided by HGNC
Primary source
HGNC:HGNC:37260
See related
Ensembl:ENSG00000250317 MIM:617465; AllianceGenome:HGNC:37260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PNX; C4orf52; MITRAC7
Summary
Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 18.0), duodenum (RPKM 16.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SMIM20 in Genome Data Viewer
Location:
4p15.2
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (25914220..25929812)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (25896311..25911902)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25915842..25931434)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723733 Neighboring gene uncharacterized LOC124900688 Neighboring gene uncharacterized LOC105374538 Neighboring gene uncharacterized LOC124900689 Neighboring gene long intergenic non-protein coding RNA 2357

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial cytochrome c oxidase assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small integral membrane protein 20
Names
mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa
phoenixin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145432.3NP_001138904.1  small integral membrane protein 20 isoform 1

    See identical proteins and their annotated locations for NP_001138904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC133961
    Consensus CDS
    CCDS47038.1
    UniProtKB/Swiss-Prot
    Q8N5G0, Q9BRT5
    Related
    ENSP00000427407.2, ENST00000506197.3
    Conserved Domains (1) summary
    pfam15061
    Location:257
    DUF4538; Domain of unknown function (DUF4538)
  2. NM_001394130.1NP_001381059.1  small integral membrane protein 20 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133961
    Consensus CDS
    CCDS93489.1
    UniProtKB/TrEMBL
    E5RH91
    Related
    ENSP00000429820.1, ENST00000514384.1
    Conserved Domains (1) summary
    pfam15061
    Location:237
    DUF4538; Domain of unknown function (DUF4538)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    25914220..25929812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    25896311..25911902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)