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ANKUB1 ankyrin repeat and ubiquitin domain containing 1 [ Homo sapiens (human) ]

Gene ID: 389161, updated on 5-Aug-2022

Summary

Official Symbol
ANKUB1provided by HGNC
Official Full Name
ankyrin repeat and ubiquitin domain containing 1provided by HGNC
Primary source
HGNC:HGNC:29642
See related
Ensembl:ENSG00000206199 AllianceGenome:HGNC:29642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf16
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ANKUB1 in Genome Data Viewer
Location:
3q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (149761100..149792554, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (152512353..152543796, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149478887..149510341, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene WW domain containing transcription regulator 1 Neighboring gene WWTR1 antisense RNA 1 Neighboring gene COMM domain containing 2 Neighboring gene RNA, U6 small nuclear 507, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5490 Neighboring gene ring finger protein 13 Neighboring gene RNA, U6 small nuclear 720, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40759

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144960.3NP_001138432.1  protein ANKUB1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC069216, AK304359, BC171805
    UniProtKB/Swiss-Prot
    A6NFN9
    UniProtKB/TrEMBL
    E9PHT4
    Related
    ENSP00000387907.1, ENST00000446160.7
    Conserved Domains (5) summary
    smart00213
    Location:178
    UBQ; Ubiquitin homologues
    cd00204
    Location:195296
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:243294
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:243271
    ANK; ANK repeat [structural motif]
    cl00155
    Location:978
    UBQ; Ubiquitin-like proteins
  2. NM_001315505.2NP_001302434.1  protein ANKUB1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 5' UTR and coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC069216, BC171805
    Conserved Domains (3) summary
    cd00204
    Location:49150
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:97148
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:97125
    ANK; ANK repeat [structural motif]
  3. NM_001315506.2NP_001302435.1  protein ANKUB1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (3) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC069216, AK304359
    Consensus CDS
    CCDS82857.1
    UniProtKB/Swiss-Prot
    A6NFN9, E9PHT4
    Related
    ENSP00000417635.2, ENST00000462519.3
    Conserved Domains (3) summary
    sd00045
    Location:243271
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:196296
    Ank_2; Ankyrin repeats (3 copies)
    cl25424
    Location:378
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    149761100..149792554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512798.2XP_011511100.1  protein ANKUB1 isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:146247
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:194245
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:194222
    ANK; ANK repeat [structural motif]
  2. XM_011512799.2XP_011511101.1  protein ANKUB1 isoform X2

    Conserved Domains (5) summary
    smart00213
    Location:178
    UBQ; Ubiquitin homologues
    cd00204
    Location:195296
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:243294
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:243271
    ANK; ANK repeat [structural motif]
    cl00155
    Location:978
    UBQ; Ubiquitin-like proteins
  3. XM_011512801.2XP_011511103.1  protein ANKUB1 isoform X3

    Conserved Domains (3) summary
    cd00204
    Location:29130
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:77128
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:77105
    ANK; ANK repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    152512353..152543796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)