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PLSCR5 phospholipid scramblase family member 5 [ Homo sapiens (human) ]

Gene ID: 389158, updated on 5-Aug-2022

Summary

Official Symbol
PLSCR5provided by HGNC
Official Full Name
phospholipid scramblase family member 5provided by HGNC
Primary source
HGNC:HGNC:19952
See related
Ensembl:ENSG00000231213 AllianceGenome:HGNC:19952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See PLSCR5 in Genome Data Viewer
Location:
3q24
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (146576555..146605346, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (149331731..149360509, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (146294342..146323133, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 1 Neighboring gene RNA, U6 small nuclear 428, pseudogene Neighboring gene long intergenic non-protein coding RNA 2010 Neighboring gene RNA, U6 small nuclear 505, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipid scramblase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in plasma membrane phospholipid scrambling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phospholipid scramblase family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085420.2NP_001078889.1  phospholipid scramblase family member 5 isoform 1

    See identical proteins and their annotated locations for NP_001078889.1

    Status: VALIDATED

    Source sequence(s)
    AC116544, AY436642
    Consensus CDS
    CCDS46931.1
    UniProtKB/Swiss-Prot
    A0PG75, B2RXK5
    Related
    ENSP00000390111.1, ENST00000443512.2
    Conserved Domains (1) summary
    pfam03803
    Location:44265
    Scramblase; Scramblase
  2. NM_001321245.2NP_001308174.1  phospholipid scramblase family member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AY436642, BC157886, BX431427
    Consensus CDS
    CCDS82853.1
    UniProtKB/Swiss-Prot
    A0PG75
    Related
    ENSP00000418626.1, ENST00000482567.5
    Conserved Domains (1) summary
    cl02043
    Location:47253
    LOR; LURP-one-related

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    146576555..146605346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006373.2XP_016861862.1  phospholipid scramblase family member 5 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    149331731..149360509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)