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ZNF662 zinc finger protein 662 [ Homo sapiens (human) ]

Gene ID: 389114, updated on 25-Jan-2022

Summary

Official Symbol
ZNF662provided by HGNC
Official Full Name
zinc finger protein 662provided by HGNC
Primary source
HGNC:HGNC:31930
See related
Ensembl:ENSG00000182983 AllianceGenome:HGNC:31930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in skin (RPKM 4.3), endometrium (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF662 in Genome Data Viewer
Location:
3p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (42906142..42919334)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42947634..42960826)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13936 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 22 Neighboring gene KRBOX1 antisense RNA 1 Neighboring gene KRAB box domain containing 1 Neighboring gene golgi associated kinase 1A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33347, FLJ45880, MGC149141

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134656.2NP_001128128.1  zinc finger protein 662 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AC092043, AK090754, AW117418, BC128085
    Consensus CDS
    CCDS46807.1
    UniProtKB/Swiss-Prot
    Q6ZS27
    Related
    ENSP00000329264.6, ENST00000328199.6
    Conserved Domains (5) summary
    smart00349
    Location:3392
    KRAB; krueppel associated box
    COG5048
    Location:272427
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:276296
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3372
    KRAB; KRAB box
    pfam13465
    Location:316341
    zf-H2C2_2; Zinc-finger double domain
  2. NM_207404.4NP_997287.2  zinc finger protein 662 isoform 1

    See identical proteins and their annotated locations for NP_997287.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate 5' exon, uses an alternate in-frame splice junction at the 5' end of an exon, and contains an alternate in-frame exon compared to variant 2. The resulting isoform (1) is shorter at the N-terminus, contains a single alternate aa, and contains an alternate segment compared to isoform 2.
    Source sequence(s)
    AC092043, AK090754, AK127779
    Consensus CDS
    CCDS2708.1
    UniProtKB/Swiss-Prot
    Q6ZS27
    Related
    ENSP00000405047.2, ENST00000440367.7
    Conserved Domains (3) summary
    COG5048
    Location:246401
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:290315
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    42906142..42919334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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