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KRT84 keratin 84 [ Homo sapiens (human) ]

Gene ID: 3890, updated on 1-Jun-2020

Summary

Official Symbol
KRT84provided by HGNC
Official Full Name
keratin 84provided by HGNC
Primary source
HGNC:HGNC:6461
See related
Ensembl:ENSG00000161849 MIM:602766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB4; KRTHB4
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KRT84 in Genome Data Viewer
Location:
12q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52377665..52386977, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52771596..52779417, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 89 pseudogene Neighboring gene keratin 85 Neighboring gene keratin 82 Neighboring gene keratin 90 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
structural constituent of epidermis IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
hair follicle development NAS
Non-traceable Author Statement
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
nail development NAS
Non-traceable Author Statement
more info
PubMed 
regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
keratin filament IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
keratin, type II cuticular Hb4
Names
K84
hard keratin, type II, 4
keratin 84, type II
keratin, hair, basic, 4
type II hair keratin 4
type II hair keratin Hb4
type-II keratin Kb24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012299.1 RefSeqGene

    Range
    4982..12822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033045.4NP_149034.2  keratin, type II cuticular Hb4

    See identical proteins and their annotated locations for NP_149034.2

    Status: REVIEWED

    Source sequence(s)
    AC078865, BC069647
    Consensus CDS
    CCDS8825.1
    UniProtKB/Swiss-Prot
    Q9NSB2
    Related
    ENSP00000257951.3, ENST00000257951.3
    Conserved Domains (5) summary
    pfam00038
    Location:165475
    Filament; Intermediate filament protein
    pfam03980
    Location:293411
    Nnf1; Nnf1
    pfam16208
    Location:16161
    Keratin_2_head; Keratin type II head
    pfam16888
    Location:215315
    DUF5082; Domain of unknown function (DUF5082)
    cl23720
    Location:375444
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52377665..52386977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538335.2XP_011536637.1  keratin, type II cuticular Hb4 isoform X1

    See identical proteins and their annotated locations for XP_011536637.1

    UniProtKB/Swiss-Prot
    Q9NSB2
    Conserved Domains (5) summary
    pfam00038
    Location:165475
    Filament; Intermediate filament protein
    pfam03980
    Location:293411
    Nnf1; Nnf1
    pfam16208
    Location:16161
    Keratin_2_head; Keratin type II head
    pfam16888
    Location:215315
    DUF5082; Domain of unknown function (DUF5082)
    cl23720
    Location:375444
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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