U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C2orf68 chromosome 2 open reading frame 68 [ Homo sapiens (human) ]

Gene ID: 388969, updated on 5-Sep-2025
Official Symbol
C2orf68provided by HGNC
Official Full Name
chromosome 2 open reading frame 68provided by HGNC
Primary source
HGNC:HGNC:34353
See related
Ensembl:ENSG00000168887 MIM:618519; AllianceGenome:HGNC:34353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCRCN81
Expression
Ubiquitous expression in ovary (RPKM 7.0), endometrium (RPKM 6.7) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See C2orf68 in Genome Data Viewer
Location:
2p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85605254..85612066, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85607314..85614126, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85832377..85839189, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11706 Neighboring gene ring finger protein 181 Neighboring gene transmembrane protein 150A Neighboring gene ubiquitin specific peptidase 39 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:85838960-85839341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16134 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:85839517-85839689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16136 Neighboring gene surfactant protein B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16138 Neighboring gene uncharacterized LOC105374842

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. NM_001013649.3 gene is down-regulated in human colorectal adenocarcinoma. Jiang Q, et al. Mol Med Rep, 2011 Nov-Dec. PMID 21874238
  2. Hcrcn81 is upregulated by rapamycin treatment in human colorectal adenocarcinoma cells. Wen X, et al. Mol Med Rep, 2013 Apr. PMID 23404111
  3. The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer. Wen X, et al. Med Oncol, 2014 Aug. PMID 25023051
  4. hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer. Chen Y, et al. Med Oncol, 2016 Jan. PMID 26607374
  5. Interaction between C2ORF68 and HuR in human colorectal cancer. Lv Z, et al. Oncol Rep, 2019 Mar. PMID 30664176

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study suggested that c2orf68 is a potential carcinogenesis factor in colorectal cancer (CRC). Furthermore, c2orf68 may have a synergistic effect with HuR in the onset and development of CRC.
    Title: Interaction between C2ORF68 and HuR in human colorectal cancer.
  2. hcrcn81 might promote carcinogenesis and progression through regulation of the Wnt/beta-catenin signaling pathway and plays an important role in the carcinogenesis of colorectal cancer.
    Title: hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer.
  3. c2orf68 expression correlates with the pathogenesis of colorectal cancer through PI3K/Akt/mTOR pathway.
    Title: The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer.
  4. Observations of the current study indicate that hcrcn81 may play a role in tumorigenesis by regulating the mTOR signaling pathway.
    Title: Hcrcn81 is upregulated by rapamycin treatment in human colorectal adenocarcinoma cells.
  5. The mRNA levels of NM_001013649.3 are significantly down-regulated in colorectal adenocarcinoma tissue, and this down-regulation is most likely correlated with the differentiation status of the cancer.
    Title: NM_001013649.3 gene is down-regulated in human colorectal adenocarcinoma.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14112, FLJ35653, MGC131675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
UPF0561 protein C2orf68

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013649.4 → NP_001013671.2  UPF0561 protein C2orf68

    See identical proteins and their annotated locations for NP_001013671.2

    Status: VALIDATED

    Source sequence(s)
    AC012454, AC016753, BC111483, BU619982, CN303296
    Consensus CDS
    CCDS42704.1
    UniProtKB/Swiss-Prot
    B4DT10, Q2NKX9, Q4G0J7, Q6ZVA6
    UniProtKB/TrEMBL
    L7T9J5
    Related
    ENSP00000304410.5, ENST00000306336.6
    Conserved Domains (1) summary
    pfam10573
    Location:5 → 126
    UPF0561; Uncharacterized protein family UPF0561

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    85605254..85612066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264305.5 → XP_005264362.1  UPF0561 protein C2orf68 isoform X1

    See identical proteins and their annotated locations for XP_005264362.1

    Conserved Domains (1) summary
    pfam10573
    Location:5 → 79
    UPF0561; Uncharacterized protein family UPF0561

  2. XM_024452879.2 → XP_024308647.1  UPF0561 protein C2orf68 isoform X1

    Conserved Domains (1) summary
    pfam10573
    Location:5 → 79
    UPF0561; Uncharacterized protein family UPF0561

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    85607314..85614126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341962.1 → XP_054197937.1  UPF0561 protein C2orf68 isoform X1

  2. XM_054341961.1 → XP_054197936.1  UPF0561 protein C2orf68 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2NKX9.1 GenPept UniProtKB/Swiss-Prot:Q2NKX9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools