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OR14A2 olfactory receptor family 14 subfamily A member 2 [ Homo sapiens (human) ]

Gene ID: 388761, updated on 22-Sep-2022

Summary

Official Symbol
OR14A2provided by HGNC
Official Full Name
olfactory receptor family 14 subfamily A member 2provided by HGNC
Primary source
HGNC:HGNC:15024
See related
Ensembl:ENSG00000241128 AllianceGenome:HGNC:15024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR5AX1; OR5AX1P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR14A2 in Genome Data Viewer
Location:
1q44
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247722957..247748158, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247153783..247178989, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247886259..247911460, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 13 subfamily G member 1 Neighboring gene olfactory receptor family 6 subfamily F member 1 Neighboring gene olfactory receptor family 14 subfamily K member 1 Neighboring gene olfactory receptor family 1 subfamily C member 1 Neighboring gene olfactory receptor family 9 subfamily H member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 14A2
Names
olfactory receptor 5AX1
olfactory receptor OR1-31
olfactory receptor, family 5, subfamily AX, member 1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355292.3NP_001342221.1  olfactory receptor 14A2

    Status: VALIDATED

    Source sequence(s)
    AC118470
    Consensus CDS
    CCDS86063.1
    UniProtKB/Swiss-Prot
    Q96R54
    UniProtKB/TrEMBL
    A0A126GWG8
    Conserved Domains (1) summary
    cd15227
    Location:23292
    7tmA_OR14-like; olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    247722957..247748158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420193.1XP_047276149.1  olfactory receptor 14A2 isoform X1

    UniProtKB/Swiss-Prot
    Q96R54
    UniProtKB/TrEMBL
    A0A126GWG8
    Related
    ENSP00000355441.1, ENST00000366485.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    247153783..247178989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002409.3: Suppressed sequence

    Description
    NG_002409.3: This RefSeq was removed because it is now thought that this locus is a transcribed gene.