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CAPN8 calpain 8 [ Homo sapiens (human) ]

Gene ID: 388743, updated on 1-Jun-2020

Summary

Official Symbol
CAPN8provided by HGNC
Official Full Name
calpain 8provided by HGNC
Primary source
HGNC:HGNC:1485
See related
Ensembl:ENSG00000203697 MIM:618777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
nCL-2
Annotation information
Note: This gene aligns across a gap in the GRCh38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_167186.2 and the 3' end was annotated on NT_004487.20 in NCBI's Homo sapiens Annotation Release 106. [17 Jun 2014]
Annotation category: suggests misassembly
Expression
Biased expression in stomach (RPKM 65.0), lung (RPKM 7.1) and 2 other tissues See more
Orthologs

Genomic context

See CAPN8 in Genome Data Viewer
Location:
1q41
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (223541609..223665734, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223714972..223853436, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 185 Neighboring gene uncharacterized LOC105373034 Neighboring gene SNRPE pseudogene 10 Neighboring gene uncharacterized LOC105373281 Neighboring gene RNA, U6 small nuclear 1248, pseudogene Neighboring gene calpain 2 Neighboring gene uncharacterized LOC105373046

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
digestion IEA
Inferred from Electronic Annotation
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calpain-8
Names
new calpain 2
stomach-specific M-type calpain
NP_001137434.1
XP_016856754.1
XP_016856755.1
XP_016856756.1
XP_016856757.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143962.2NP_001137434.1  calpain-8

    See identical proteins and their annotated locations for NP_001137434.1

    Status: VALIDATED

    Source sequence(s)
    BC157893, BG187068, BM739137, BM843240, DA874912, FO681503
    Consensus CDS
    CCDS73038.1
    UniProtKB/Swiss-Prot
    A6NHC0
    Related
    ENSP00000355837.6, ENST00000366872.10
    Conserved Domains (4) summary
    PTZ00183
    Location:618692
    PTZ00183; centrin; Provisional
    cd00051
    Location:580635
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:46342
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:356509
    Calpain_III; Calpain large subunit, domain III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    223541609..223665734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001265.1XP_016856754.1  calpain-8 isoform X1

  2. XM_017001266.1XP_016856755.1  calpain-8 isoform X2

  3. XM_017001267.2XP_016856756.1  calpain-8 isoform X3

  4. XM_017001268.1XP_016856757.1  calpain-8 isoform X4

    UniProtKB/TrEMBL
    B1B154
    Related
    ENSP00000355838.2, ENST00000366873.6
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