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Clk Clock [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38872, updated on 2-Nov-2019

Summary

Official Symbol
Clkprovided by FlyBase
Official Full Name
Clockprovided by FlyBase
Primary source
FLYBASE:FBgn0023076
Locus tag
Dmel_CG7391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLHe10; CG7391; clk; CLK; clock; CLOCK; dClck; dclk; dClk; dCLK; dCLK/JRK; dClock; dCLOCK; Dmel\CG7391; Jerk; jrk; Jrk; PAS1

Genomic context

See Clk in Genome Data Viewer
Location:
66A12-66A12; 3-21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7763233..7775603, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7756333..7768703, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Henna Neighboring gene uncharacterized protein Neighboring gene PAR-domain protein 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Circadian rhythm - fly, organism-specific biosystem (from KEGG)
    Circadian rhythm - fly, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In the fruit fly Drosophila melanogaster, seven genes ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase II regulatory region sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
behavioral response to cocaine NAS
Non-traceable Author Statement
more info
PubMed 
behavioral response to cocaine TAS
Traceable Author Statement
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm NAS
Non-traceable Author Statement
more info
PubMed 
circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
eclosion rhythm NAS
Non-traceable Author Statement
more info
PubMed 
eclosion rhythm TAS
Traceable Author Statement
more info
PubMed 
entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotor rhythm NAS
Non-traceable Author Statement
more info
PubMed 
locomotor rhythm TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to light stimulus IDA
Inferred from Direct Assay
more info
PubMed 
response to temperature stimulus IDA
Inferred from Direct Assay
more info
PubMed 
response to temperature stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic behavior TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CLOCK-BMAL transcription complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
clock
Names
CG7391-PA
CG7391-PD
CG7391-PF
CG7391-PG
CG7391-PH
CLOCK
Clk-PA
Clk-PD
Clk-PF
Clk-PG
Clk-PH
dClock

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7763233..7775603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079240.3NP_523964.2  clock, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523964.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61735
    Related
    FBpp0076500, FBtr0076785
    Conserved Domains (4) summary
    smart00091
    Location:89149
    PAS; PAS domain
    cd00083
    Location:1264
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:260362
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:261364
    PAS_11; PAS domain
  2. NM_206299.2NP_996021.2  clock, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996021.2

    Status: REVIEWED

    Related
    FBpp0306710, FBtr0334648
    Conserved Domains (2) summary
    cd00130
    Location:132234
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:133236
    PAS_11; PAS domain
  3. NM_001014574.2NP_001014574.1  clock, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014574.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61735
    Related
    FBpp0099480, FBtr0100134
    Conserved Domains (3) summary
    smart00091
    Location:2787
    PAS; PAS domain
    cd00130
    Location:198300
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:199302
    PAS_11; PAS domain
  4. NM_001014576.2NP_001014576.1  clock, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014576.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61735
    Related
    FBpp0099478, FBtr0100132
    Conserved Domains (4) summary
    smart00091
    Location:93153
    PAS; PAS domain
    cd00083
    Location:1668
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:264366
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:265368
    PAS_11; PAS domain
  5. NM_170628.2NP_729294.2  clock, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729294.2

    Status: REVIEWED

    Related
    FBpp0306709, FBtr0334647
    Conserved Domains (2) summary
    cd00130
    Location:132234
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam14598
    Location:133236
    PAS_11; PAS domain
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