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NOTCH2NLA notch 2 N-terminal like A [ Homo sapiens (human) ]

Gene ID: 388677, updated on 29-Mar-2020

Summary

Official Symbol
NOTCH2NLAprovided by HGNC
Official Full Name
notch 2 N-terminal like Aprovided by HGNC
Primary source
HGNC:HGNC:31862
See related
Ensembl:ENSG00000264343 MIM:618023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N2N; NOTCH2NL
Expression
Ubiquitous expression in testis (RPKM 12.1), skin (RPKM 6.6) and 25 other tissues See more

Genomic context

See NOTCH2NLA in Genome Data Viewer
Location:
1q21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (146151908..146229032, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145176379..145286270)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1719 Neighboring gene NBPF member 10 Neighboring gene uncharacterized LOC105371254 Neighboring gene RNA, U6 small nuclear 1071, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of notch 2 N-terminal like (NOTCH2NL) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NBPF10

Clone Names

  • FLJ35032, FLJ55807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
notch homolog 2 N-terminal-like protein A
Names
Notch homolog 2 N-terminal like protein
notch homolog 2 N-terminal-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364006.1NP_001350935.1  notch homolog 2 N-terminal-like protein A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at a 5' exon compared to variant 1. This difference is predicted to result in the use of an upstream start codon and an isoform (2) with a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AC239799
    Conserved Domains (1) summary
    cd00054
    Location:156192
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. NM_203458.4NP_982283.2  notch homolog 2 N-terminal-like protein A isoform 1

    See identical proteins and their annotated locations for NP_982283.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1
    Source sequence(s)
    AC239799, BC010154, BM792637
    Consensus CDS
    CCDS72880.1
    UniProtKB/Swiss-Prot
    Q7Z3S9
    Related
    ENSP00000354929.6, ENST00000362074.7
    Conserved Domains (1) summary
    cd00054
    Location:143179
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    146151908..146229032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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