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DIPK1A divergent protein kinase domain 1A [ Homo sapiens (human) ]

Gene ID: 388650, updated on 1-Jun-2020

Summary

Official Symbol
DIPK1Aprovided by HGNC
Official Full Name
divergent protein kinase domain 1Aprovided by HGNC
Primary source
HGNC:HGNC:32213
See related
Ensembl:ENSG00000154511 MIM:614542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM69A
Summary
This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in brain (RPKM 13.7), fat (RPKM 8.8) and 24 other tissues See more
Orthologs

Genomic context

See DIPK1A in Genome Data Viewer
Location:
1p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (92832729..92961522, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93298286..93427079, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ecotropic viral integration site 5 Neighboring gene cyclin J pseudogene 2 Neighboring gene H3 histone pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene small nucleolar RNA, H/ACA box 66 Neighboring gene ribosomal protein L5 Neighboring gene meiotic nuclear divisions 1 homolog (S. cerevisiae) pseudogene Neighboring gene RNA, U6 small nuclear 970, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 692, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

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NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23493

Gene Ontology Provided by GOA

Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
divergent protein kinase domain 1A
Names
family with sequence similarity 69 member A
protein FAM69A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033051.1 RefSeqGene

    Range
    5001..133794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006605.5NP_001006606.2  divergent protein kinase domain 1A isoform 1

    See identical proteins and their annotated locations for NP_001006606.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL162740, AL702320
    Consensus CDS
    CCDS44173.1
    UniProtKB/Swiss-Prot
    Q5T7M9
    Related
    ENSP00000359333.4, ENST00000370310.5
    Conserved Domains (2) summary
    pfam12260
    Location:194396
    PIP49_C; Protein-kinase domain of FAM69
    pfam14875
    Location:20176
    PIP49_N; N-term cysteine-rich ER, FAM69
  2. NM_001252269.1NP_001239198.1  divergent protein kinase domain 1A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL162740, DB199113, DB475309
    Consensus CDS
    CCDS72823.1
    UniProtKB/TrEMBL
    A0A087X2C2
    Related
    ENSP00000484866.1, ENST00000613902.4
    Conserved Domains (2) summary
    pfam12260
    Location:149351
    PIP49_C; Protein-kinase domain of FAM69
    pfam14875
    Location:19131
    PIP49_N; N-term cysteine-rich ER, FAM69
  3. NM_001252270.1NP_001239199.1  divergent protein kinase domain 1A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL162740, BF979329, DB475309, DB498496
    Consensus CDS
    CCDS72824.1
    UniProtKB/TrEMBL
    A0A087WZK6
    Related
    ENSP00000482718.1, ENST00000616709.4
    Conserved Domains (2) summary
    pfam12260
    Location:135337
    PIP49_C; Protein-kinase domain of FAM69
    pfam14875
    Location:20108
    PIP49_N; N-term cysteine-rich ER, FAM69
  4. NM_001252271.1NP_001239200.1  divergent protein kinase domain 1A isoform 4

    See identical proteins and their annotated locations for NP_001239200.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL162740, DA141589, DA155419, DA348631
    Consensus CDS
    CCDS72822.1
    UniProtKB/TrEMBL
    A0A087WZ97
    Related
    ENSP00000482478.1, ENST00000613047.4
    Conserved Domains (2) summary
    pfam12260
    Location:169371
    PIP49_C; Protein-kinase domain of FAM69
    pfam14875
    Location:1151
    PIP49_N; N-term cysteine-rich ER, FAM69
  5. NM_001252273.1NP_001239202.1  divergent protein kinase domain 1A isoform 5

    See identical proteins and their annotated locations for NP_001239202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate terminal exon, which results in a frameshift and different 3' UTR, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC070342, DA736826, DB475309
    Consensus CDS
    CCDS72825.1
    UniProtKB/Swiss-Prot
    Q5T7M9
    Related
    ENSP00000483279.1, ENST00000615519.4
    Conserved Domains (1) summary
    pfam14875
    Location:20159
    PIP49_N; N-term cysteine-rich ER, FAM69

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    92832729..92961522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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