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GBP7 guanylate binding protein 7 [ Homo sapiens (human) ]

Gene ID: 388646, updated on 21-Dec-2019

Summary

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Official Symbol
GBP7provided by HGNC
Official Full Name
guanylate binding protein 7provided by HGNC
Primary source
HGNC:HGNC:29606
See related
Ensembl:ENSG00000213512 MIM:612468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP4L
Summary
Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]
Expression
Biased expression in liver (RPKM 25.8) and lung (RPKM 0.3) See more
Orthologs
all

Genomic context

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See GBP7 in Genome Data Viewer
Location:
1p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (89131742..89176003, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89597434..89641723, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prostaglandin E synthase 3 pseudogene 1 Neighboring gene uncharacterized LOC112268267 Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC105378842 Neighboring gene guanylate binding protein 4 Neighboring gene uncharacterized LOC107985076

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Olszewski MA, et al. J Interferon Cytokine Res, 2006 May. PMID 16689661
  2. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. Eid NA, et al. Malar J, 2010 May 8. PMID 20459687, Free PMC Article
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: GBP2

Homology

Clone Names

  • FLJ38822

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
  
symbiont-containing vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
guanylate-binding protein 7
Names
GBP-7
GTP-binding protein 7
guanine nucleotide-binding protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207398.3 → NP_997281.2  guanylate-binding protein 7

    See identical proteins and their annotated locations for NP_997281.2

    Status: VALIDATED

    Source sequence(s)
    AC104459, AK096141
    Consensus CDS
    CCDS720.1
    UniProtKB/Swiss-Prot
    Q8N8V2
    Related
    ENSP00000294671.2, ENST00000294671.3
    Conserved Domains (3) summary
    pfam02841
    Location:283 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18 → 281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    89131742..89176003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8V2.2 GenPept UniProtKB/Swiss-Prot:Q8N8V2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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