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GBP7 guanylate binding protein 7 [ Homo sapiens (human) ]

Gene ID: 388646, updated on 9-Jun-2025
Official Symbol
GBP7provided by HGNC
Official Full Name
guanylate binding protein 7provided by HGNC
Primary source
HGNC:HGNC:29606
See related
Ensembl:ENSG00000213512 MIM:612468; AllianceGenome:HGNC:29606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP4L
Summary
Guanylate-binding proteins, such as GBP7, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]
Expression
Biased expression in liver (RPKM 25.8) and lung (RPKM 0.3) See more
Orthologs
all
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See GBP7 in Genome Data Viewer
Location:
1p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (89131742..89176003, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (88975111..89019382, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89597425..89641686, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5145 Neighboring gene prostaglandin E synthase 3 pseudogene 1 Neighboring gene uncharacterized LOC112268267 Neighboring gene Sharpr-MPRA regulatory region 4932 Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC105378842 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:89614414-89615613 Neighboring gene uncharacterized LOC107985076 Neighboring gene Sharpr-MPRA regulatory region 13956 Neighboring gene guanylate binding protein 4 Neighboring gene guanylate binding protein family member 6 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:89725724-89726225 Neighboring gene guanylate binding protein 5

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways. Feng M, et al. J Virol, 2021 Feb 24. PMID 33408175, Free PMC Article
  2. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. Olszewski MA, et al. J Interferon Cytokine Res, 2006 May. PMID 16689661
  3. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. Eid NA, et al. Malar J, 2010 May 8. PMID 20459687, Free PMC Article
  4. Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders. Pintacuda G, et al. Cell Genom, 2023 Mar 8. PMID 36950384, Free PMC Article
  5. Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure. Michael ARM, et al. Nat Commun, 2024 Oct 2. PMID 39358380, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-kappaB and JAK-STAT Signaling Pathways.
    Title: Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: GBP2

Homology

Clone Names

  • FLJ38822

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytolysis in another organism ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to protozoan ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of type III interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
guanylate-binding protein 7
Names
GBP-7
GTP-binding protein 7
guanine nucleotide-binding protein 7

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207398.3 → NP_997281.2  guanylate-binding protein 7

    See identical proteins and their annotated locations for NP_997281.2

    Status: VALIDATED

    Source sequence(s)
    AC104459, AK096141
    Consensus CDS
    CCDS720.1
    UniProtKB/Swiss-Prot
    Q8N8V2
    Related
    ENSP00000294671.2, ENST00000294671.3
    Conserved Domains (3) summary
    pfam02841
    Location:283 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18 → 281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    89131742..89176003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    88975111..89019382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8V2.2 GenPept UniProtKB/Swiss-Prot:Q8N8V2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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