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KRT35 keratin 35 [ Homo sapiens (human) ]

Gene ID: 3886, updated on 11-Sep-2019

Summary

Official Symbol
KRT35provided by HGNC
Official Full Name
keratin 35provided by HGNC
Primary source
HGNC:HGNC:6453
See related
Ensembl:ENSG00000197079 MIM:602764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA5; K35; Ha-5; hHa5; KRTHA5
Summary
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KRT35 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41476689..41482743, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39632941..39637392, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 43 pseudogene Neighboring gene keratin 32 Neighboring gene RNA, U2 small nuclear 32, pseudogene Neighboring gene keratin 36 Neighboring gene keratin 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cuticular Ha5
Names
HHa5 hair keratin type I intermediate filament
hair keratin, type I Ha5
hard keratin, type I, 5
keratin 35, type I
keratin, hair, acidic, 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012292.1 RefSeqGene

    Range
    5001..9452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002280.4NP_002271.3  keratin, type I cuticular Ha5

    See identical proteins and their annotated locations for NP_002271.3

    Status: REVIEWED

    Source sequence(s)
    AC019349, X90763
    Consensus CDS
    CCDS11394.2
    UniProtKB/Swiss-Prot
    Q92764
    Related
    ENSP00000377558.1, ENST00000393989.1
    Conserved Domains (1) summary
    pfam00038
    Location:96407
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41476689..41482743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524794.1XP_011523096.1  keratin, type I cuticular Ha5 isoform X1

    See identical proteins and their annotated locations for XP_011523096.1

    UniProtKB/Swiss-Prot
    Q92764
    Related
    ENSP00000246639.2, ENST00000246639.6
    Conserved Domains (1) summary
    pfam00038
    Location:96407
    Filament; Intermediate filament protein
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