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ZNF888 zinc finger protein 888 [ Homo sapiens (human) ]

Gene ID: 388559, updated on 1-Aug-2020

Summary

Official Symbol
ZNF888provided by HGNC
Official Full Name
zinc finger protein 888provided by HGNC
Primary source
HGNC:HGNC:38695
See related
Ensembl:ENSG00000213793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in urinary bladder (RPKM 7.4), prostate (RPKM 5.4) and 24 other tissues See more
Orthologs

Genomic context

See ZNF888 in Genome Data Viewer
Location:
19q13.41
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52904790..52929161, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53409168..53426930, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 468 Neighboring gene zinc finger protein 320 Neighboring gene ZNF816-ZNF321P readthrough Neighboring gene zinc finger protein 321, pseudogene Neighboring gene zinc finger protein 816 Neighboring gene zinc finger protein 702, pseudogene Neighboring gene uncharacterized LOC105372453

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 888
Names
CTD-2331H12.6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310127.2NP_001297056.1  zinc finger protein 888 isoform b

    See identical proteins and their annotated locations for NP_001297056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AC010487
    Consensus CDS
    CCDS86801.1
    UniProtKB/TrEMBL
    A0A1W2PQ69
    Conserved Domains (4) summary
    COG5048
    Location:324708
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:748
    KRAB; KRAB box
    pfam13465
    Location:284308
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001384652.1NP_001371581.1  zinc finger protein 888 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC010487
  3. NM_001384653.1NP_001371582.1  zinc finger protein 888 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC010487
  4. NM_001384654.1NP_001371583.1  zinc finger protein 888 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform c.
    Source sequence(s)
    AC010487
  5. NM_001384655.1NP_001371584.1  zinc finger protein 888 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform c.
    Source sequence(s)
    AC010487
  6. NM_001384656.1NP_001371585.1  zinc finger protein 888 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AC010487

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52904790..52929161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026798.2XP_016882287.1  zinc finger protein 888 isoform X1

  2. XM_005259451.5XP_005259508.1  zinc finger protein 888 isoform X2

    See identical proteins and their annotated locations for XP_005259508.1

    UniProtKB/TrEMBL
    A0A1W2PQ69
    Related
    ENSP00000491567.1, ENST00000638862.1
    Conserved Domains (4) summary
    COG5048
    Location:324708
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:748
    KRAB; KRAB box
    pfam13465
    Location:284308
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026799.2XP_016882288.1  zinc finger protein 888 isoform X2

    UniProtKB/TrEMBL
    A0A1W2PQ69
    Conserved Domains (4) summary
    COG5048
    Location:324708
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:748
    KRAB; KRAB box
    pfam13465
    Location:284308
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017026800.2XP_016882289.1  zinc finger protein 888 isoform X3

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