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IGFL3 IGF like family member 3 [ Homo sapiens (human) ]

Gene ID: 388555, updated on 13-May-2022

Summary

Official Symbol
IGFL3provided by HGNC
Official Full Name
IGF like family member 3provided by HGNC
Primary source
HGNC:HGNC:32930
See related
Ensembl:ENSG00000188624 MIM:610546; AllianceGenome:HGNC:32930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ483
Summary
IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IGFL3 in Genome Data Viewer
Location:
19q13.32
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46120067..46124688, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48947474..48952095, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46623324..46627945, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IGF like family member 4 Neighboring gene IGF like family member 2 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene TGFB induced factor homeobox 1 pseudogene 1 Neighboring gene uncharacterized LOC105372424

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin growth factor-like family member 3
Names
RPRC483

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207393.2NP_997276.1  insulin growth factor-like family member 3 precursor

    See identical proteins and their annotated locations for NP_997276.1

    Status: VALIDATED

    Source sequence(s)
    AC007785, AY358434
    Consensus CDS
    CCDS33058.1
    UniProtKB/Swiss-Prot
    Q6UXB1
    Related
    ENSP00000344860.2, ENST00000341415.3
    Conserved Domains (1) summary
    pfam14653
    Location:33115
    IGFL; Insulin growth factor-like family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46120067..46124688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526953.3XP_011525255.1  insulin growth factor-like family member 3 isoform X1

    Conserved Domains (1) summary
    pfam14653
    Location:27115
    IGFL; Insulin growth factor-like family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48947474..48952095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)