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CLEC17A C-type lectin domain containing 17A [ Homo sapiens (human) ]

Gene ID: 388512, updated on 11-Jun-2021

Summary

Official Symbol
CLEC17Aprovided by HGNC
Official Full Name
C-type lectin domain containing 17Aprovided by HGNC
Primary source
HGNC:HGNC:34520
See related
Ensembl:ENSG00000187912 MIM:616838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in lymph node (RPKM 5.2), spleen (RPKM 3.9) and 4 other tissues See more
Orthologs
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Genomic context

See CLEC17A in Genome Data Viewer
Location:
19p13.12
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (14580777..14612035)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14693896..14722847)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene trans-2,3-enoyl-CoA reductase Neighboring gene uncharacterized LOC112268253 Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene RNA, 7SL, cytoplasmic 337, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 842, pseudogene Neighboring gene adhesion G protein-coupled receptor E3 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene uncharacterized LOC107985308

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45910

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fucose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mannose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-type lectin domain family 17, member A
Names
C-type lectin domain family 17 member A
prolectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204118.2NP_001191047.1  C-type lectin domain family 17, member A isoform 1

    See identical proteins and their annotated locations for NP_001191047.1

    Status: VALIDATED

    Source sequence(s)
    AC010527, AC135052, AC140008, BC140848
    Consensus CDS
    CCDS56087.1
    UniProtKB/Swiss-Prot
    Q6ZS10
    Related
    ENSP00000393719.2, ENST00000417570.6
    Conserved Domains (1) summary
    cd03590
    Location:254374
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  2. NM_207390.4NP_997273.3  C-type lectin domain family 17, member A isoform 2

    See identical proteins and their annotated locations for NP_997273.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010527, AC135052, AC140008
    Consensus CDS
    CCDS46002.2
    UniProtKB/Swiss-Prot
    Q6ZS10
    Related
    ENSP00000450065.1, ENST00000547437.5
    Conserved Domains (1) summary
    smart00034
    Location:254298
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

RNA

  1. NR_109784.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010527, AC135052, AC140008, AK127809, BC144664
  2. NR_109785.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010527, AC135052, AC140008, AK127809, BC144665

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    14580777..14612035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026788.2XP_016882277.1  C-type lectin domain family 17, member A isoform X1

    Conserved Domains (1) summary
    cd03590
    Location:186306
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  2. XM_017026794.1XP_016882283.1  C-type lectin domain family 17, member A isoform X6

  3. XM_017026793.1XP_016882282.1  C-type lectin domain family 17, member A isoform X5

  4. XM_017026792.1XP_016882281.1  C-type lectin domain family 17, member A isoform X4

  5. XM_017026790.2XP_016882279.1  C-type lectin domain family 17, member A isoform X2

  6. XM_017026791.2XP_016882280.1  C-type lectin domain family 17, member A isoform X3

  7. XM_017026787.2XP_016882276.1  C-type lectin domain family 17, member A isoform X1

    Conserved Domains (1) summary
    cd03590
    Location:186306
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  8. XM_017026785.2XP_016882274.1  C-type lectin domain family 17, member A isoform X1

    Conserved Domains (1) summary
    cd03590
    Location:186306
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  9. XM_017026786.2XP_016882275.1  C-type lectin domain family 17, member A isoform X1

    Conserved Domains (1) summary
    cd03590
    Location:186306
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
  10. XM_017026789.2XP_016882278.1  C-type lectin domain family 17, member A isoform X1

    Conserved Domains (1) summary
    cd03590
    Location:186306
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
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