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KRT34 keratin 34 [ Homo sapiens (human) ]

Gene ID: 3885, updated on 21-Dec-2019

Summary

Official Symbol
KRT34provided by HGNC
Official Full Name
keratin 34provided by HGNC
Primary source
HGNC:HGNC:6452
See related
Ensembl:ENSG00000131737 MIM:602763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA4; Ha-4; hHa4; KRTHA4
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KRT34 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41377665..41383816, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39533921..39538636, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371778 Neighboring gene keratin 33B Neighboring gene keratin 31 Neighboring gene uncharacterized LOC100505782 Neighboring gene keratin 41 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cuticular Ha4
Names
K34
hair keratin, type I Ha4
hard keratin, type I, 4
keratin 34, type I
keratin, hair, acidic, 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012291.1 RefSeqGene

    Range
    5001..9716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021013.3NP_066293.2  keratin, type I cuticular Ha4

    See identical proteins and their annotated locations for NP_066293.2

    Status: REVIEWED

    Source sequence(s)
    Y16790
    Consensus CDS
    CCDS11390.1
    UniProtKB/Swiss-Prot
    O76011
    Related
    ENSP00000377570.2, ENST00000394001.1
    Conserved Domains (1) summary
    pfam00038
    Location:97408
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41377665..41383816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524793.2XP_011523095.1  keratin, type I cuticular Ha4 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:73384
    Filament; Intermediate filament protein

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315953.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    57880..62596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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