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INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 388324, updated on 7-Jun-2020

Summary

Official Symbol
INCA1provided by HGNC
Official Full Name
inhibitor of CDK, cyclin A1 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:32224
See related
Ensembl:ENSG00000196388 MIM:617374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD45
Expression
Broad expression in testis (RPKM 10.5), prostate (RPKM 1.7) and 21 other tissues See more
Orthologs

Genomic context

See INCA1 in Genome Data Viewer
Location:
17p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4988130..5006093, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4891425..4901214, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 2 Neighboring gene microRNA 6864 Neighboring gene microRNA 6865 Neighboring gene uncharacterized LOC101927979 Neighboring gene kinesin family member 1C Neighboring gene KIF1C antisense RNA 1 Neighboring gene uncharacterized LOC105371502 Neighboring gene uncharacterized LOC105371501

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC148150, MGC148151

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167985.1NP_001161457.1  protein INCA1 isoform 2

    See identical proteins and their annotated locations for NP_001161457.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AY601907, AY604176
    Consensus CDS
    CCDS11064.1
    UniProtKB/Swiss-Prot
    Q0VD86
    Related
    ENSP00000461844.1, ENST00000575780.5
    Conserved Domains (1) summary
    pfam15142
    Location:12175
    INCA1; INCA1
  2. NM_001167986.1NP_001161458.1  protein INCA1 isoform 1

    See identical proteins and their annotated locations for NP_001161458.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AY601906, AY604176, BC119781
    Consensus CDS
    CCDS54074.1
    UniProtKB/Swiss-Prot
    Q0VD86
    Conserved Domains (1) summary
    pfam15142
    Location:12190
    INCA1; INCA1
  3. NM_001167987.1NP_001161459.1  protein INCA1 isoform 1

    See identical proteins and their annotated locations for NP_001161459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AY601906, AY604176, BC122873
    Consensus CDS
    CCDS54074.1
    UniProtKB/Swiss-Prot
    Q0VD86
    Conserved Domains (1) summary
    pfam15142
    Location:12190
    INCA1; INCA1
  4. NM_213726.2NP_998891.2  protein INCA1 isoform 2

    See identical proteins and their annotated locations for NP_998891.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Both variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AY601906, AY604176
    Consensus CDS
    CCDS11064.1
    UniProtKB/Swiss-Prot
    Q0VD86
    Related
    ENSP00000347129.3, ENST00000355025.7
    Conserved Domains (1) summary
    pfam15142
    Location:12175
    INCA1; INCA1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4988130..5006093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450745.1XP_024306513.1  protein INCA1 isoform X1

    Conserved Domains (1) summary
    pfam15142
    Location:12190
    INCA1; INCA1
  2. XM_006721518.2XP_006721581.1  protein INCA1 isoform X2

    See identical proteins and their annotated locations for XP_006721581.1

    UniProtKB/Swiss-Prot
    Q0VD86
    Conserved Domains (1) summary
    pfam15142
    Location:12175
    INCA1; INCA1
  3. XM_024450746.1XP_024306514.1  protein INCA1 isoform X2

    Conserved Domains (1) summary
    pfam15142
    Location:12175
    INCA1; INCA1
  4. XM_005256627.3XP_005256684.1  protein INCA1 isoform X1

    See identical proteins and their annotated locations for XP_005256684.1

    UniProtKB/Swiss-Prot
    Q0VD86
    Conserved Domains (1) summary
    pfam15142
    Location:12190
    INCA1; INCA1
  5. XM_024450744.1XP_024306512.1  protein INCA1 isoform X1

    Conserved Domains (1) summary
    pfam15142
    Location:12190
    INCA1; INCA1
  6. XM_011523832.3XP_011522134.1  protein INCA1 isoform X1

    See identical proteins and their annotated locations for XP_011522134.1

    UniProtKB/Swiss-Prot
    Q0VD86
    Related
    ENSP00000458316.1, ENST00000574617.1
    Conserved Domains (1) summary
    pfam15142
    Location:12190
    INCA1; INCA1
  7. XM_005256629.1XP_005256686.1  protein INCA1 isoform X2

    See identical proteins and their annotated locations for XP_005256686.1

    UniProtKB/Swiss-Prot
    Q0VD86
    Conserved Domains (1) summary
    pfam15142
    Location:12175
    INCA1; INCA1
  8. XM_006721517.1XP_006721580.1  protein INCA1 isoform X1

    See identical proteins and their annotated locations for XP_006721580.1

    UniProtKB/Swiss-Prot
    Q0VD86
    Related
    ENSP00000460673.1, ENST00000576820.5
    Conserved Domains (1) summary
    pfam15142
    Location:12190
    INCA1; INCA1
  9. XM_006721519.3XP_006721582.1  protein INCA1 isoform X2

    See identical proteins and their annotated locations for XP_006721582.1

    UniProtKB/Swiss-Prot
    Q0VD86
    Conserved Domains (1) summary
    pfam15142
    Location:12175
    INCA1; INCA1
  10. XM_005256628.5XP_005256685.1  protein INCA1 isoform X1

    See identical proteins and their annotated locations for XP_005256685.1

    UniProtKB/Swiss-Prot
    Q0VD86
    Conserved Domains (1) summary
    pfam15142
    Location:12190
    INCA1; INCA1
  11. XM_011523834.2XP_011522136.1  protein INCA1 isoform X3

    Conserved Domains (1) summary
    pfam15142
    Location:12137
    INCA1; INCA1
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