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KRT33A keratin 33A [ Homo sapiens (human) ]

Gene ID: 3883, updated on 1-Jun-2020

Summary

Official Symbol
KRT33Aprovided by HGNC
Official Full Name
keratin 33Aprovided by HGNC
Primary source
HGNC:HGNC:6450
See related
Ensembl:ENSG00000006059 MIM:602761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA3I; K33A; Ha-3I; Krt1-3; hHa3-I; KRTHA3A
Summary
This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KRT33A in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41345704..41350828, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39502344..39507064, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin associated protein 17-1 Neighboring gene TBC1 domain family member 3 pseudogene 7 Neighboring gene uncharacterized LOC105371778 Neighboring gene keratin 33B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cuticular Ha3-I
Names
hair keratin, type I Ha3-I
hard keratin, type I,3I
keratin 33A, type I
keratin, hair, acidic, 3A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012289.1 RefSeqGene

    Range
    4977..9713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004138.4NP_004129.2  keratin, type I cuticular Ha3-I

    See identical proteins and their annotated locations for NP_004129.2

    Status: REVIEWED

    Source sequence(s)
    AC003958, AJ633621
    Consensus CDS
    CCDS11388.1
    UniProtKB/Swiss-Prot
    O76009
    Related
    ENSP00000007735.3, ENST00000007735.4
    Conserved Domains (1) summary
    pfam00038
    Location:55366
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41345704..41350828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524786.3XP_011523088.1  keratin, type I cuticular Ha3-I isoform X1

    See identical proteins and their annotated locations for XP_011523088.1

    Conserved Domains (1) summary
    pfam00038
    Location:37207
    Filament; Intermediate filament protein

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315953.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    89433..94169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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