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KRT32 keratin 32 [ Homo sapiens (human) ]

Gene ID: 3882, updated on 21-Dec-2019

Summary

Official Symbol
KRT32provided by HGNC
Official Full Name
keratin 32provided by HGNC
Primary source
HGNC:HGNC:6449
See related
Ensembl:ENSG00000108759 MIM:602760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA2; HKA2; hHa2; KRTHA2
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 1.2) and skin (RPKM 0.7) See more
Orthologs

Genomic context

See KRT32 in Genome Data Viewer
Location:
17q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41459513..41469252, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39615765..39623638, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 38 Neighboring gene keratin 43 pseudogene Neighboring gene RNA, U2 small nuclear 32, pseudogene Neighboring gene keratin 35 Neighboring gene keratin 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cuticular Ha2
Names
K32
hair keratin, type I Ha2
hard keratin, type I, 2
keratin 32, type I
keratin, hair, acidic, 2
type I cuticular hair keratin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012424.1 RefSeqGene

    Range
    5001..12874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002278.3NP_002269.3  keratin, type I cuticular Ha2

    See identical proteins and their annotated locations for NP_002269.3

    Status: REVIEWED

    Source sequence(s)
    AC019349, AI190798, X81419
    Consensus CDS
    CCDS11393.1
    UniProtKB/Swiss-Prot
    Q14532
    Related
    ENSP00000225899.3, ENST00000225899.3
    Conserved Domains (3) summary
    pfam00038
    Location:95406
    Filament; Intermediate filament protein
    pfam04871
    Location:112230
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    cl09111
    Location:275355
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41459513..41469252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_934457.1 RNA Sequence

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