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INSYN1 inhibitory synaptic factor 1 [ Homo sapiens (human) ]

Gene ID: 388135, updated on 26-Oct-2022

Summary

Official Symbol
INSYN1provided by HGNC
Official Full Name
inhibitory synaptic factor 1provided by HGNC
Primary source
HGNC:HGNC:33753
See related
Ensembl:ENSG00000205363 MIM:617128; AllianceGenome:HGNC:33753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C15orf59
Summary
Predicted to be involved in inhibitory postsynaptic potential. Predicted to be active in postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 6.6), heart (RPKM 2.3) and 12 other tissues See more
Orthologs
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Genomic context

See INSYN1 in Genome Data Viewer
Location:
15q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (73735458..73753351, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (71552818..71570722, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74027799..74045692, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370891 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr15:73988946-73989458 and GRCh37_chr15:73989459-73989969 Neighboring gene CD276 molecule Neighboring gene INSYN1 antisense RNA 1 Neighboring gene uncharacterized LOC105370892

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in inhibitory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
inhibitory synaptic factor 1
Names
UPF0583 protein C15orf59
inhibitory synaptic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039614.3NP_001034703.1  inhibitory synaptic factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001034703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC022188
    Consensus CDS
    CCDS32289.1
    UniProtKB/Swiss-Prot
    Q2T9L4
    Related
    ENSP00000457205.1, ENST00000569673.3
    Conserved Domains (1) summary
    pfam15252
    Location:52280
    DUF4589; Domain of unknown function (DUF4589)
  2. NM_001303254.2NP_001290183.1  inhibitory synaptic factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC022188
    Conserved Domains (1) summary
    pfam15252
    Location:24252
    DUF4589; Domain of unknown function (DUF4589)
  3. NM_001384351.1NP_001371280.1  inhibitory synaptic factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022188
    Consensus CDS
    CCDS32289.1
    UniProtKB/Swiss-Prot
    Q2T9L4
    Conserved Domains (1) summary
    pfam15252
    Location:52280
    DUF4589; Domain of unknown function (DUF4589)
  4. NM_001384352.1NP_001371281.1  inhibitory synaptic factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022188
    Conserved Domains (1) summary
    pfam15252
    Location:1139
    DUF4589; Domain of unknown function (DUF4589)
  5. NM_001384353.1NP_001371282.1  inhibitory synaptic factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022188
    Conserved Domains (1) summary
    pfam15252
    Location:1139
    DUF4589; Domain of unknown function (DUF4589)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    73735458..73753351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432489.1XP_047288445.1  inhibitory synaptic factor 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    71552818..71570722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)