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TNFAIP8L3 TNF alpha induced protein 8 like 3 [ Homo sapiens (human) ]

Gene ID: 388121, updated on 7-Jun-2020

Summary

Official Symbol
TNFAIP8L3provided by HGNC
Official Full Name
TNF alpha induced protein 8 like 3provided by HGNC
Primary source
HGNC:HGNC:20620
See related
Ensembl:ENSG00000183578 MIM:616438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIPE3
Expression
Broad expression in endometrium (RPKM 16.6), esophagus (RPKM 6.5) and 15 other tissues See more
Orthologs

Genomic context

See TNFAIP8L3 in Genome Data Viewer
Location:
15q21.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (51056601..51105276, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (51348798..51397473, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene 30 Neighboring gene adaptor related protein complex 4 subunit epsilon 1 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 3 Neighboring gene MIR4713 host gene Neighboring gene Sharpr-MPRA regulatory region 8572 Neighboring gene Sharpr-MPRA regulatory region 3311 Neighboring gene Sharpr-MPRA regulatory regions 2939 and 12041 Neighboring gene cytochrome P450 family 19 subfamily A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41287

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
inositol lipid-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tumor necrosis factor alpha-induced protein 8-like protein 3
Names
TNF alpha-induced protein 8-like protein 3
TNFAIP8-like protein 3
tumor necrosis factor, alpha induced protein 8 like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311175.2NP_001298104.1  tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001298104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC073964, AK123281, CA447540, HY052681
    Consensus CDS
    CCDS81881.1
    UniProtKB/Swiss-Prot
    Q5GJ75
    UniProtKB/TrEMBL
    A0A1B0GTK8
    Related
    ENSP00000489743.1, ENST00000637513.2
    Conserved Domains (1) summary
    pfam05527
    Location:23201
    DUF758; Domain of unknown function (DUF758)
  2. NM_207381.3NP_997264.2  tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_997264.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY517501, CA447540
    Consensus CDS
    CCDS32241.1
    UniProtKB/Swiss-Prot
    Q5GJ75
    Related
    ENSP00000328016.5, ENST00000327536.5
    Conserved Domains (1) summary
    pfam05527
    Location:111289
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    51056601..51105276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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