Format

Send to:

Choose Destination

KRT31 keratin 31 [ Homo sapiens (human) ]

Gene ID: 3881, updated on 7-Jun-2020

Summary

Official Symbol
KRT31provided by HGNC
Official Full Name
keratin 31provided by HGNC
Primary source
HGNC:HGNC:6448
See related
Ensembl:ENSG00000094796 MIM:601077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA1; Ha-1; hHa1; KRTHA1
Summary
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 18.4) and esophagus (RPKM 9.5) See more
Orthologs

Genomic context

See KRT31 in Genome Data Viewer
Location:
17q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41393721..41397608, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39549976..39553844, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 33B Neighboring gene keratin 34 Neighboring gene uncharacterized LOC100505782 Neighboring gene keratin 41 pseudogene Neighboring gene keratin 37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138630

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cuticular Ha1
Names
K31
hair keratin, type I Ha1
hard keratin, type I, 1
keratin 31, type I
keratin, hair, acidic,1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012288.1 RefSeqGene

    Range
    4985..8872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002277.3NP_002268.2  keratin, type I cuticular Ha1

    See identical proteins and their annotated locations for NP_002268.2

    Status: REVIEWED

    Source sequence(s)
    AC003958
    Consensus CDS
    CCDS11391.1
    UniProtKB/Swiss-Prot
    Q15323
    Related
    ENSP00000251645.2, ENST00000251645.3
    Conserved Domains (1) summary
    pfam00038
    Location:55366
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41393721..41397608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315953.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    35353..39240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center