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ENO4 enolase 4 [ Homo sapiens (human) ]

Gene ID: 387712, updated on 23-Nov-2021

Summary

Official Symbol
ENO4provided by HGNC
Official Full Name
enolase 4provided by HGNC
Primary source
HGNC:HGNC:31670
See related
Ensembl:ENSG00000188316 MIM:131375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf134
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ENO4 in Genome Data Viewer
Location:
10q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (116848230..116911803)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118609010..118642112)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene Sharpr-MPRA regulatory region 690 Neighboring gene microRNA 9851 Neighboring gene shootin 1 Neighboring gene VISTA enhancer hs841 Neighboring gene ventral anterior homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • AC023283.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cilium organization IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm principal piece IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
enolase 4
Names
2-phospho-D-glycerate hydro-lyase
enolase family member 4
enolase-like protein ENO4
NP_001229628.1
XP_005269872.1
XP_006717898.1
XP_011538099.1
XP_011538101.1
XP_016871730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242699.2NP_001229628.1  enolase 4

    Status: VALIDATED

    Source sequence(s)
    AC023283
    Consensus CDS
    CCDS73206.1
    UniProtKB/TrEMBL
    J3KNX1
    Related
    ENSP00000345555.6, ENST00000341276.11
    Conserved Domains (2) summary
    TIGR01060
    Location:68568
    eno; phosphopyruvate hydratase
    cl21457
    Location:70567
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    116848230..116911803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717835.3XP_006717898.1  enolase 4 isoform X1

    Conserved Domains (2) summary
    TIGR01060
    Location:68568
    eno; phosphopyruvate hydratase
    cl21457
    Location:70567
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
  2. XM_011539797.3XP_011538099.1  enolase 4 isoform X2

    Conserved Domains (2) summary
    TIGR01060
    Location:68526
    eno; phosphopyruvate hydratase
    cl21457
    Location:70525
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
  3. XM_017016241.2XP_016871730.1  enolase 4 isoform X3

  4. XM_011539799.3XP_011538101.1  enolase 4 isoform X4

    Conserved Domains (1) summary
    cl21457
    Location:70404
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
  5. XM_005269815.3XP_005269872.1  enolase 4 isoform X5

    Conserved Domains (1) summary
    cl21457
    Location:70404
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RNA

  1. XR_001747107.1 RNA Sequence

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