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GPR15LG G protein-coupled receptor 15 ligand [ Homo sapiens (human) ]

Gene ID: 387695, updated on 29-Oct-2022

Summary

Official Symbol
GPR15LGprovided by HGNC
Official Full Name
G protein-coupled receptor 15 ligandprovided by HGNC
Primary source
HGNC:HGNC:31428
See related
Ensembl:ENSG00000188373 MIM:617775; AllianceGenome:HGNC:31428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP57; CSBF; AP-57; GPR15L; UNQ1833; C10orf99
Summary
Enables chemokine activity. Involved in several processes, including defense response to other organism; lymphocyte chemotaxis; and negative regulation of cell cycle G1/S phase transition. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon (RPKM 85.6), esophagus (RPKM 74.6) and 3 other tissues See more
Orthologs
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Genomic context

See GPR15LG in Genome Data Viewer
Location:
10q23.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (84173801..84185294)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (85052266..85063813)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (85933557..85945050)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene growth hormone inducible transmembrane protein Neighboring gene competing endogenous lncRNA 2 for microRNA let-7b Neighboring gene cadherin related family member 1 Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Clone Names

  • FLJ21763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein GPR15LG; protein GPR15L
Names
RLLV1833
anti-microbial peptide with 57 amino acid residues
antimicrobial peptide with 57 amino acid residues
antimicrobial peptide-57
colon-derived SUSD2 binding factor
protein GPR15 ligand
secreted protein C10orf99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207373.3NP_997256.1  protein GPR15LG precursor

    See identical proteins and their annotated locations for NP_997256.1

    Status: VALIDATED

    Source sequence(s)
    AI831407, AW351839, AY358751
    Consensus CDS
    CCDS7371.1
    UniProtKB/Swiss-Prot
    Q6UWK7
    Related
    ENSP00000361199.3, ENST00000372126.4
    Conserved Domains (1) summary
    pfam15854
    Location:1780
    DUF4725; Domain of unknown function (DUF4725)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    84173801..84185294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269811.4XP_005269868.1  protein GPR15L isoform X1

    Conserved Domains (1) summary
    pfam15854
    Location:1753
    DUF4725; Domain of unknown function (DUF4725)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    85052266..85063813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)