U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR15LG G protein-coupled receptor 15 ligand [ Homo sapiens (human) ]

Gene ID: 387695, updated on 12-Jun-2025
Official Symbol
GPR15LGprovided by HGNC
Official Full Name
G protein-coupled receptor 15 ligandprovided by HGNC
Primary source
HGNC:HGNC:31428
See related
Ensembl:ENSG00000188373 MIM:617775; AllianceGenome:HGNC:31428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP57; CSBF; AP-57; GPR15L; UNQ1833; C10orf99
Summary
Enables chemokine activity. Involved in several processes, including defense response to other organism; mast cell degranulation; and negative regulation of cell cycle G1/S phase transition. Located in extracellular region. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in colon (RPKM 85.6), esophagus (RPKM 74.6) and 3 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See GPR15LG in Genome Data Viewer
Location:
10q23.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (84173801..84185294)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (85052266..85063813)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (85933557..85945050)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:85899203-85899772 Neighboring gene growth hormone inducible transmembrane protein Neighboring gene NANOG hESC enhancer GRCh37_chr10:85915068-85915581 Neighboring gene NANOG hESC enhancer GRCh37_chr10:85920657-85921158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:85921491-85922206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85931151-85931652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3677 Neighboring gene competing endogenous lncRNA 2 for microRNA let-7b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85936583-85937084 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:85939583-85940403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2551 Neighboring gene cadherin related family member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85963048-85963548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85963549-85964049 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:85974015-85974538 Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The Role of GPR15 Function in Blood and Vasculature. Bauer M. Int J Mol Sci, 2021 Oct 6. PMID 34639163, Free PMC Article
  2. C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes. Chen C, et al. Sci Rep, 2018 Jun 5. PMID 29872130, Free PMC Article
  3. Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15. Zhang Z, et al. Cell Discov, 2024 Jun 25. PMID 38918398, Free PMC Article
  4. GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes. Chen C, et al. Biosci Rep, 2024 Jun 26. PMID 38393364, Free PMC Article
  5. Tyrosine sulfation and O-glycosylation of chemoattractant receptor GPR15 differentially regulate interaction with GPR15L. Okamoto Y, et al. J Cell Sci, 2021 Apr 15. PMID 33758080, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes.
    Title: GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes.
  2. Results indicate that chromosome 10 open reading frame 99 protein (C10orf99) plays a contributive role in psoriasis pathogenesis and may serve as a new target for psoriasis treatment.
    Title: C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes.
  3. Compared with other antimicrobial peptides, AP-57 has its distinct characteristics, including longer sequence length, four cysteines, highly cationic character, cell-specific toxicity, DNA binding and tissue-specific expressing patterns.
    Title: AP-57/C10orf99 is a new type of multifunctional antimicrobial peptide.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Markers

Homology

Clone Names

  • FLJ21763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables chemokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chemokine activity IEA
Inferred from Electronic Annotation
more info
  
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within T cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to fungus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lymphocyte chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lymphocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell cycle G1/S phase transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of T cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein GPR15LG
Names
RLLV1833
anti-microbial peptide with 57 amino acid residues
antimicrobial peptide with 57 amino acid residues
antimicrobial peptide-57
colon-derived SUSD2 binding factor
protein GPR15 ligand
protein GPR15L
secreted protein C10orf99

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207373.3 → NP_997256.1  protein GPR15LG precursor

    See identical proteins and their annotated locations for NP_997256.1

    Status: VALIDATED

    Source sequence(s)
    AI831407, AW351839, AY358751
    Consensus CDS
    CCDS7371.1
    UniProtKB/Swiss-Prot
    Q6UWK7
    Related
    ENSP00000361199.3, ENST00000372126.4
    Conserved Domains (1) summary
    pfam15854
    Location:17 → 80
    DUF4725; Domain of unknown function (DUF4725)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    84173801..84185294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269811.4 → XP_005269868.1  protein GPR15LG isoform X1

    Conserved Domains (1) summary
    pfam15854
    Location:17 → 53
    DUF4725; Domain of unknown function (DUF4725)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    85052266..85063813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365882.1 → XP_054221857.1  protein GPR15LG isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UWK7.1 GenPept UniProtKB/Swiss-Prot:Q6UWK7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools