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WASHC2A WASH complex subunit 2A [ Homo sapiens (human) ]

Gene ID: 387680, updated on 15-Jun-2019

Summary

Official Symbol
WASHC2Aprovided by HGNC
Official Full Name
WASH complex subunit 2Aprovided by HGNC
Primary source
HGNC:HGNC:23416
See related
Ensembl:ENSG00000099290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM21A; FAM21B; bA98I6.1; bA56A21.1
Expression
Ubiquitous expression in heart (RPKM 26.3), bone marrow (RPKM 21.0) and 25 other tissues See more
Orthologs

Genomic context

See WASHC2A in Genome Data Viewer
Location:
10q11.23
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (50067888..50133509)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51827610..51893269)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 23 homolog B Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 Neighboring gene family with sequence similarity 21, member A pseudogene Neighboring gene solute carrier family 9 member 3 pseudogene 3 Neighboring gene solute carrier family 9 member 3 pseudogene 1 Neighboring gene N-acylsphingosine amidohydrolase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Expression of the Risp family decreases the amounts of HIV-1 Gag expression in infected astrocytes PubMed
Rev rev Expression of the Risp family in human brain tissues and astrocytes can inhibit Rev activity by inducing accumulation of Rev in the cytoplasm PubMed
rev Co-localization of human 16.4.1 and HIV-1 Rev is demonstrated by epifluorescence microscopy of HeLa 16.4.1-GFP cells transfected with a Rev-CFP expression construct PubMed
rev Yeast-two hybrid screening and mammalian two-hybrid assays show the interaction of human 16.4.1 protein with HIV-1 Rev; amino acid residues 38-39 and 59-60 in Rev interact with a 95 amino acid region (residues 39-133) in a human protein fragment 16.4.1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18670, FLJ43157, KIAA0592

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
WASH complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WASH complex subunit 2A
Names
WASH complex subunit FAM21A
WASH complex subunit FAM21B
alternative protein FAM21B
family with sequence similarity 21 member A
family with sequence similarity 21, member B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005751.3NP_001005751.1  WASH complex subunit 2A isoform 1

    See identical proteins and their annotated locations for NP_001005751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC065500, BC075815, BC082258, DC336167
    Consensus CDS
    CCDS41527.1
    UniProtKB/Swiss-Prot
    Q641Q2
    UniProtKB/TrEMBL
    Q6P0Q7
    Related
    ENSP00000282633.5, ENST00000282633.10
    Conserved Domains (1) summary
    pfam15255
    Location:9491076
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  2. NM_001291398.1NP_001278327.1  WASH complex subunit 2A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AL442003, BC065500, BC075815, BC082258, DC336167
    Consensus CDS
    CCDS76303.1
    UniProtKB/Swiss-Prot
    Q641Q2
    UniProtKB/TrEMBL
    Q6P0Q7
    Related
    ENSP00000344037.6, ENST00000351071.11
    Conserved Domains (1) summary
    pfam15255
    Location:9301055
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  3. NM_001330102.2NP_001317031.1  WASH complex subunit 2A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AL442003, AL450382, BC065500
    Consensus CDS
    CCDS81463.1
    UniProtKB/TrEMBL
    E7ESD2, Q6P0Q7
    Related
    ENSP00000314417.7, ENST00000314664.12
    Conserved Domains (1) summary
    pfam15255
    Location:8891014
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    50067888..50133509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016230.1XP_016871719.1  WASH complex subunit 2A isoform X7

  2. XM_017016234.1XP_016871723.1  WASH complex subunit 2A isoform X13

  3. XM_024447992.1XP_024303760.1  WASH complex subunit 2A isoform X14

    Conserved Domains (1) summary
    pfam15255
    Location:314450
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  4. XM_017016227.1XP_016871716.1  WASH complex subunit 2A isoform X3

  5. XM_011539786.2XP_011538088.1  WASH complex subunit 2A isoform X11

    Conserved Domains (1) summary
    pfam15255
    Location:886943
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  6. XM_006717831.3XP_006717894.2  WASH complex subunit 2A isoform X6

    Conserved Domains (1) summary
    pfam15255
    Location:8981025
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  7. XM_017016231.1XP_016871720.1  WASH complex subunit 2A isoform X8

  8. XM_005269807.3XP_005269864.2  WASH complex subunit 2A isoform X2

    Conserved Domains (1) summary
    pfam15255
    Location:9201047
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  9. XM_017016229.1XP_016871718.1  WASH complex subunit 2A isoform X5

  10. XM_005269806.3XP_005269863.2  WASH complex subunit 2A isoform X1

    Conserved Domains (1) summary
    pfam15255
    Location:9251052
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  11. XM_017016228.1XP_016871717.1  WASH complex subunit 2A isoform X4

  12. XM_006717832.3XP_006717895.2  WASH complex subunit 2A isoform X10

    UniProtKB/TrEMBL
    A0A087WYF6
    Related
    ENSP00000481763.1, ENST00000611324.4
    Conserved Domains (1) summary
    pfam15255
    Location:855980
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  13. XM_017016232.1XP_016871721.1  WASH complex subunit 2A isoform X9

  14. XM_024447993.1XP_024303761.1  WASH complex subunit 2A isoform X16

    Conserved Domains (1) summary
    pfam15255
    Location:295429
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  15. XM_017016233.1XP_016871722.1  WASH complex subunit 2A isoform X12

    Related
    ENSP00000382277.2, ENST00000399339.6
  16. XM_017016235.1XP_016871724.1  WASH complex subunit 2A isoform X14

    Conserved Domains (1) summary
    pfam15255
    Location:314450
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  17. XM_024447991.1XP_024303759.1  WASH complex subunit 2A isoform X14

    Conserved Domains (1) summary
    pfam15255
    Location:314450
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  18. XM_005269810.3XP_005269867.2  WASH complex subunit 2A isoform X15

    Conserved Domains (1) summary
    pfam15255
    Location:317444
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RNA

  1. XR_001747105.2 RNA Sequence

  2. XR_002956976.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018232.1: Suppressed sequence

    Description
    NM_018232.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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