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PEDS1-UBE2V1 PEDS1-UBE2V1 readthrough [ Homo sapiens (human) ]

Gene ID: 387522, updated on 23-Nov-2021

Summary

Official Symbol
PEDS1-UBE2V1provided by HGNC
Official Full Name
PEDS1-UBE2V1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33521
See related
Ensembl:ENSG00000124208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CROC1B; CROC-1B; KUA-UEV; TMEM189-UBE2V1
Summary
The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in brain (RPKM 35.8), placenta (RPKM 35.8) and 25 other tissues See more
Orthologs
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Genomic context

See PEDS1-UBE2V1 in Genome Data Viewer
Location:
20q13.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (50081124..50153723, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48697661..48770260, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene translation regulatory long non-coding RNA 1 Neighboring gene uncharacterized LOC105372655 Neighboring gene ubiquitin conjugating enzyme E2 V1 Neighboring gene plasmanylethanolamine desaturase 1 Neighboring gene long intergenic non-protein coding RNA 1275 Neighboring gene long intergenic non-protein coding RNA 1273

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
TMEM189-UBE2V1 fusion protein
Names
TMEM189-UBE2V1 readthrough transcript
transmembrane protein 189-ubiquitin-conjugating enzyme E2 variant 1 read-through

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199203.3NP_954673.2  TMEM189-UBE2V1 fusion protein

    Status: REVIEWED

    Source sequence(s)
    AL034423
    Related
    ENSP00000344166.2, ENST00000341698.2
    Conserved Domains (2) summary
    smart00212
    Location:239365
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    pfam10520
    Location:85251
    TMEM189_B_dmain; B domain of TMEM189, localization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    50081124..50153723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003349.4: Suppressed sequence

    Description
    NM_003349.4: This RefSeq was permanently suppressed because the CDS was partial.
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