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KRT18 keratin 18 [ Homo sapiens (human) ]

Gene ID: 3875, updated on 13-Jun-2021

Summary

Official Symbol
KRT18provided by HGNC
Official Full Name
keratin 18provided by HGNC
Primary source
HGNC:HGNC:6430
See related
Ensembl:ENSG00000111057 MIM:148070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K18; CK-18; CYK18
Summary
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 258.0), colon (RPKM 230.1) and 15 other tissues See more
Orthologs
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Genomic context

See KRT18 in Genome Data Viewer
Location:
12q13.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52948855..52952906)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53342639..53346690)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 41 Neighboring gene microRNA 9898 Neighboring gene keratin 8 Neighboring gene KRT18 locus control region Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC283335 Neighboring gene tensin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi to plasma membrane CFTR protein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cholangiocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cornification TAS
Traceable Author Statement
more info
 
involved_in extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in intermediate filament cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in keratinization TAS
Traceable Author Statement
more info
 
involved_in mesenchymal stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to fructose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in adherens junction HDA PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in keratin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 18
Names
cell proliferation-inducing gene 46 protein
cytokeratin 18
keratin 18, type I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008351.1 RefSeqGene

    Range
    5248..9036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000224.3NP_000215.1  keratin, type I cytoskeletal 18

    See identical proteins and their annotated locations for NP_000215.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC107016, CD106591, X12881
    Consensus CDS
    CCDS31809.1
    UniProtKB/Swiss-Prot
    P05783
    UniProtKB/TrEMBL
    A0A024RAY2
    Related
    ENSP00000373487.3, ENST00000388835.4
    Conserved Domains (1) summary
    pfam00038
    Location:79391
    Filament; Intermediate filament protein
  2. NM_199187.2NP_954657.1  keratin, type I cytoskeletal 18

    See identical proteins and their annotated locations for NP_954657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC107016, BG753529, CD106591, X12881
    Consensus CDS
    CCDS31809.1
    UniProtKB/Swiss-Prot
    P05783
    UniProtKB/TrEMBL
    A0A024RAY2
    Related
    ENSP00000373489.2, ENST00000388837.6
    Conserved Domains (1) summary
    pfam00038
    Location:79391
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52948855..52952906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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