GluRIA Glutamate receptor IA [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GluRIAprovided by FlyBase
Official Full Name: Glutamate receptor IAprovided by FlyBase
Primary source: FLYBASE:FBgn0004619
Locus tag: Dmel_CG8442
See related: AllianceGenome:FB:FBgn0004619
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8442; DGluR-I; dglur-IA; DGluR-IA; dGluRI; DGluRI; DmelGlu-R1; Dmel\CG8442; Dro GluRIA; Glu-R1; Glu-RI; GluR1; GluR1A; GluRI; GluRIIA
Summary: Enables kainate selective glutamate receptor activity. Involved in monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of ionotropic glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in several structures, including CNS glial cell; adult head; dorsal ectoderm anlage; ganglia; and larval midline neurons. Used to study central nervous system disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 67; autosomal recessive intellectual developmental disorder 76; epilepsy; schizophrenia; and syndromic X-linked intellectual disability 94. Orthologous to several human genes including GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: 65C1-65C1; 3-17 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6624032..6635059)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6617132..6628159)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-gated receptor activity	IEA Inferred from Electronic Annotation more info
enables kainate selective glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ionotropic glutamate receptor complex	IC Inferred by Curator more info	PubMed
part_of ionotropic glutamate receptor complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor IA

Names: CG8442-PA; GluRIA-PA; glutamate receptor; glutamate receptor I; glutamate receptor kainate-selective subunit; glutamate receptor subunit; kainate receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6624032..6635059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057507.4 → NP_476855.1 glutamate receptor IA

See identical proteins and their annotated locations for NP_476855.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B6IDJ5, Q03445, Q86PC2, Q9VRX9

Related

FBpp0076691

Conserved Domains (4) summary

cd06380
Location:41 → 453

PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor

cd13715
Location:477 → 879

PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:612 → 907

Lig_chan; Ligand-gated ion channel

pfam01094
Location:53 → 434

ANF_receptor; Receptor family ligand binding region