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TBPL2 TATA-box binding protein like 2 [ Homo sapiens (human) ]

Gene ID: 387332, updated on 23-Jun-2022

Summary

Official Symbol
TBPL2provided by HGNC
Official Full Name
TATA-box binding protein like 2provided by HGNC
Primary source
HGNC:HGNC:19841
See related
Ensembl:ENSG00000182521 MIM:608964; AllianceGenome:HGNC:19841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TBP2; TRF3
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in DNA-templated transcription, initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TBPL2 in Genome Data Viewer
Location:
14q22.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55414210..55440616, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49619941..49646349, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55880928..55907334, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene F-box protein 34 Neighboring gene autophagy related 14 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 6 Neighboring gene ribosomal protein L7a pseudogene 4 Neighboring gene abl interactor 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TATA box binding protein like 2 (TBPL2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in female germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TATA box-binding protein-like 2
Names
TATA box-binding protein-like protein 2
TATA box-binding protein-related factor 3
TBP-like 2
TBP-like protein 2
TBP-related factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199047.3NP_950248.2  TATA box-binding protein-like 2

    Status: VALIDATED

    Source sequence(s)
    AL356801
    Consensus CDS
    CCDS9724.1
    Related
    ENSP00000247219.6, ENST00000247219.6
    Conserved Domains (1) summary
    PLN00062
    Location:167342
    PLN00062; TATA-box-binding protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    55414210..55440616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    49619941..49646349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)