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TBPL2 TATA-box binding protein like 2 [ Homo sapiens (human) ]

Gene ID: 387332, updated on 5-Apr-2020

Summary

Official Symbol
TBPL2provided by HGNC
Official Full Name
TATA-box binding protein like 2provided by HGNC
Primary source
HGNC:HGNC:19841
See related
Ensembl:ENSG00000182521 MIM:608964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TBP2; TRF3
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TBPL2 in Genome Data Viewer
Location:
14q22.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (55414210..55440545, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55880928..55907263, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene autophagy related 14 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 1 Neighboring gene uncharacterized LOC107984664 Neighboring gene ribosomal protein L21 pseudogene 6 Neighboring gene ribosomal protein L7a pseudogene 4 Neighboring gene abl interactor 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TATA box binding protein like 2 (TBPL2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA polymerase III preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIIIB complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TATA box-binding protein-like protein 2
Names
TATA box-binding protein-related factor 3
TBP-like protein 2
TBP-related factor 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199047.2NP_950248.1  TATA box-binding protein-like protein 2

    See identical proteins and their annotated locations for NP_950248.1

    Status: VALIDATED

    Source sequence(s)
    AL356801, AY457923
    Consensus CDS
    CCDS9724.1
    UniProtKB/Swiss-Prot
    Q6SJ96
    Related
    ENSP00000247219.5, ENST00000247219.5
    Conserved Domains (3) summary
    PLN00062
    Location:199374
    PLN00062; TATA-box-binding protein; Provisional
    cd04516
    Location:199372
    TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...
    pfam05937
    Location:79131
    EB1_binding; EB-1 Binding Domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    55414210..55440545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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