U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG10226 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38725, updated on 8-Mar-2025

Summary

Go to the top of the page Help
Official Symbol
CG10226provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035695
Locus tag
Dmel_CG10226
See related
AllianceGenome:FB:FBgn0035695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AMT; DmCG10226; Dmel\CG10226
Summary
Predicted to enable ABC-type xenobiotic transporter activity and efflux transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Predicted to be located in plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including cholestasis (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG10226 in Genome Data Viewer
Location:
65A10-65A10; 3-16 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6234323..6240068, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6227423..6233168, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene BG642312 Neighboring gene uncharacterized protein Neighboring gene Multi drug resistance 65 Neighboring gene Bestrophin 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster. Chahine S, et al. J Insect Physiol, 2009 Oct. PMID 19545574
  2. Cellular and molecular organization of the Drosophila foregut. Zhu H, et al. Proc Natl Acad Sci U S A, 2024 Mar 12. PMID 38442150, Free PMC Article
  3. The genetic basis of incipient sexual isolation in Drosophila melanogaster. Yamamoto A, et al. Proc Biol Sci, 2024 Aug. PMID 39045689, Free PMC Article
  4. Characterization of a novel pesticide transporter and P-glycoprotein orthologues in Drosophila melanogaster. Denecke S, et al. Proc Biol Sci, 2022 May 25. PMID 35582794, Free PMC Article
  5. X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Wan D, et al. Hum Mol Genet, 2015 Aug 15. PMID 26002102

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables efflux transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in renal tubular secretion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
ABC multidrug transporter
CG10226-PA
CG10226-PB
NP_001261473.1
NP_648040.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6234323..6240068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139783.2 → NP_648040.1  uncharacterized protein Dmel_CG10226, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648040.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRW2
    Related
    FBpp0076720
    Conserved Domains (3) summary
    cd03249
    Location:414 → 649
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:81 → 1311
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:749 → 1019
    ABC_membrane; ABC transporter transmembrane region

  2. NM_001274544.1 → NP_001261473.1  uncharacterized protein Dmel_CG10226, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261473.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEB5
    Conserved Domains (3) summary
    cd03249
    Location:300 → 535
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:39 → 1197
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:635 → 905
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEB5 M9PEB5
Q95SM0 Q95SM0
Q9VRW2 Q9VRW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools