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Mir124a-1 microRNA 124a-1 [ Mus musculus (house mouse) ]

Gene ID: 387233, updated on 9-May-2024

Summary

Official Symbol
Mir124a-1provided by MGI
Official Full Name
microRNA 124a-1provided by MGI
Primary source
MGI:MGI:2676807
See related
Ensembl:ENSMUSG00000065597 miRBase:MI0000716; AllianceGenome:MGI:2676807
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mirn124a; Mirn124a-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See Mir124a-1 in Genome Data Viewer
Location:
14 D1; 14 33.77 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (64828106..64828190)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64590657..64590741)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene methionine sulfoxide reductase A Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:64942459-64942678 Neighboring gene predicted gene, 52131 Neighboring gene STARR-seq mESC enhancer starr_36939 Neighboring gene STARR-seq mESC enhancer starr_36940 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65053006-65053159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65059749-65059936 Neighboring gene predicted gene, 52130 Neighboring gene STARR-seq mESC enhancer starr_36941 Neighboring gene STARR-seq mESC enhancer starr_36942 Neighboring gene STARR-seq mESC enhancer starr_36944 Neighboring gene Mir124-1 host gene (non-protein coding) Neighboring gene STARR-seq mESC enhancer starr_36945 Neighboring gene microRNA 3078 Neighboring gene STARR-seq mESC enhancer starr_36948 Neighboring gene predicted gene, 36924

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Other Names

  • mmu-mir-124-1
  • mmu-mir-124a-1

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of exit from mitosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retinal cone cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retinal cone cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029813.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC134898
    Related
    ENSMUST00000083663.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    64828106..64828190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)