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LanA Laminin A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38723, updated on 26-Aug-2021

Summary

Official Symbol
LanAprovided by FlyBase
Official Full Name
Laminin Aprovided by FlyBase
Primary source
FLYBASE:FBgn0002526
Locus tag
Dmel_CG10236
Gene type
protein coding
RNA name
laminin A
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5]]; alpha3/5; alpha[[3; CG10236; CT28769; Dmel\CG10236; FBgn0002526; FBtr0077014; hdln; Lam; Lam-A; lamA; LamA; laminin alpha3/5; Lan; lanA; LM-A/alpha1; LMalpha1
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Genomic context

See LanA in Genome Data Viewer
Location:
65A8-65A9; 3-16 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6203831..6218022, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6196931..6211122, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Transportin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the LanA gene: The LanA gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, and frog.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dorsal trunk growth, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
laminin A
Names
CG10236-PA
LanA-PA
alpha3,5 laminin
headline
laminin
laminin A chain
laminin A subunit
laminin A5
laminin alpha
laminin alpha-chain
laminin alpha3,5
laminin alpha[[3,5]]
lamininA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6203831..6218022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057269.3NP_476617.1  laminin A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476617.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q00174
    Related
    FBpp0076722, FBtr0077014
    Conserved Domains (11) summary
    smart00136
    Location:18271
    LamNT; Laminin N-terminal domain (domain VI)
    smart00180
    Location:18591907
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:16321760
    LamB; Laminin B domain
    smart00282
    Location:30783205
    LamG; Laminin G domain
    COG0840
    Location:22782662
    Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
    cd00055
    Location:631673
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:28783029
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd02795
    Location:831966
    CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily
    pfam00053
    Location:541589
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:21292385
    Laminin_I; Laminin Domain I
    pfam06009
    Location:25662700
    Laminin_II; Laminin Domain II
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