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NPSR1 neuropeptide S receptor 1 [ Homo sapiens (human) ]

Gene ID: 387129, updated on 5-Jan-2022

Summary

Official Symbol
NPSR1provided by HGNC
Official Full Name
neuropeptide S receptor 1provided by HGNC
Primary source
HGNC:HGNC:23631
See related
Ensembl:ENSG00000187258 MIM:608595
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPRA; NPSR; VRR1; ASRT2; PGR14; GPR154
Summary
This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NPSR1 in Genome Data Viewer
Location:
7p14.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (34658218..34878332)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (34697830..34917944)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene BMP binding endothelial regulator Neighboring gene VISTA enhancer hs1336 Neighboring gene RNA, U6 small nuclear 438, pseudogene Neighboring gene NPSR1 antisense RNA 1 Neighboring gene ribosomal protein L7 pseudogene 31 Neighboring gene RNA, 7SL, cytoplasmic 132, pseudogene Neighboring gene non-SMC condensin I complex subunit D2 pseudogene 1 Neighboring gene uncharacterized LOC102724723 Neighboring gene dpy-19 like C-mannosyltransferase 1 Neighboring gene microRNA 548n Neighboring gene uncharacterized LOC105375228 Neighboring gene DPY19L2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Asthma-related traits, susceptibility to, 2
MedGen: C1837811 OMIM: 608584 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neuropeptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vasopressin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptide S receptor
Names
G-protein coupled receptor 154
G-protein coupled receptor PGR14
G-protein coupled receptor for asthma susceptibility
vasopressin receptor-related receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012185.2 RefSeqGene

    Range
    4934..225048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300933.2NP_001287862.1  neuropeptide S receptor isoform B short

    See identical proteins and their annotated locations for NP_001287862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and uses an alternate 3-terminal exon, compared to variant 1. The encoded isoform (B short, 15947423) is shorter and has a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC005493, AK172847, AY310328
    Consensus CDS
    CCDS75580.1
    UniProtKB/Swiss-Prot
    Q6W5P4
    Related
    ENSP00000433258.1, ENST00000531252.5
    Conserved Domains (1) summary
    pfam00001
    Location:66319
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001300934.2NP_001287863.1  neuropeptide S receptor isoform F

    See identical proteins and their annotated locations for NP_001287863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (F, PMID: 15947423) is shorter, compared to isoform A.
    Source sequence(s)
    AC005493, AK172847, AY310332
    Consensus CDS
    CCDS75581.1
    UniProtKB/Swiss-Prot
    Q6W5P4
    Related
    ENSP00000370953.1, ENST00000381542.5
    Conserved Domains (1) summary
    pfam00001
    Location:95264
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001300935.2NP_001287864.1  neuropeptide S receptor isoform G

    See identical proteins and their annotated locations for NP_001287864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (G) has a longer and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC005493, AK172847, AY310326, AY956448
    Consensus CDS
    CCDS75579.1
    UniProtKB/Swiss-Prot
    Q6W5P4
    Related
    ENSP00000370950.3, ENST00000381539.3
    Conserved Domains (1) summary
    pfam00001
    Location:66330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. NM_207172.2NP_997055.1  neuropeptide S receptor isoform A

    See identical proteins and their annotated locations for NP_997055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform A (PMID: 15947423).
    Source sequence(s)
    AC005493, AY310326
    Consensus CDS
    CCDS5444.1
    UniProtKB/Swiss-Prot
    Q6W5P4
    UniProtKB/TrEMBL
    A0A090N8Z1
    Related
    ENSP00000353788.1, ENST00000360581.6
    Conserved Domains (1) summary
    pfam00001
    Location:66330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. NM_207173.2NP_997056.1  neuropeptide S receptor isoform B

    See identical proteins and their annotated locations for NP_997056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (B, PMID: 15947423) has a longer and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC005493, AY310327
    Consensus CDS
    CCDS5443.1
    UniProtKB/Swiss-Prot
    Q6W5P4
    Related
    ENSP00000352839.1, ENST00000359791.5
    Conserved Domains (1) summary
    cd15197
    Location:50341
    7tmA_NPSR; neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    34658218..34878332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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