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SUMO4 small ubiquitin like modifier 4 [ Homo sapiens (human) ]

Gene ID: 387082, updated on 5-Jan-2022

Summary

Official Symbol
SUMO4provided by HGNC
Official Full Name
small ubiquitin like modifier 4provided by HGNC
Primary source
HGNC:HGNC:21181
See related
Ensembl:ENSG00000177688 MIM:608829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IDDM5; SMT3H4; SUMO-4; dJ281H8.4
Summary
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See SUMO4 in Genome Data Viewer
Location:
6q25.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149400262..149401278)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149721398..149722414)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1 (MAP3K7) binding protein 2 Neighboring gene RNA, 7SL, cytoplasmic 234, pseudogene Neighboring gene fatty acid binding protein 12 pseudogene 1 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene coiled-coil domain containing 59 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SUMO ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
small ubiquitin-related modifier 4
Names
SMT3 suppressor of mif two 3 homolog 2
SMT3 suppressor of mif two 3 homolog 4
insulin-dependent diabetes mellitus 5
small ubiquitin-like modifier 4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012301.1 RefSeqGene

    Range
    4904..5920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002255.2NP_001002255.1  small ubiquitin-related modifier 4

    See identical proteins and their annotated locations for NP_001002255.1

    Status: REVIEWED

    Source sequence(s)
    AL031133, AY340238
    Consensus CDS
    CCDS34549.1
    UniProtKB/Swiss-Prot
    Q6EEV6
    Related
    ENSP00000318635.4, ENST00000326669.6
    Conserved Domains (1) summary
    cd01763
    Location:893
    Sumo; Small ubiquitin-related modifier (SUMO)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    149400262..149401278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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