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ZKSCAN4 zinc finger with KRAB and SCAN domains 4 [ Homo sapiens (human) ]

Gene ID: 387032, updated on 10-Oct-2019

Summary

Official Symbol
ZKSCAN4provided by HGNC
Official Full Name
zinc finger with KRAB and SCAN domains 4provided by HGNC
Primary source
HGNC:HGNC:13854
See related
Ensembl:ENSG00000187626 MIM:611643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF307; ZNF427; ZSCAN36; P1P373C6
Expression
Ubiquitous expression in testis (RPKM 2.9), spleen (RPKM 2.1) and 24 other tissues See more
Orthologs

Genomic context

See ZKSCAN4 in Genome Data Viewer
Location:
6p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (28241697..28259258, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28212404..28227030, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transducer of ERBB2, 2 pseudogene 1 Neighboring gene zinc finger and SCAN domain containing 9 Neighboring gene NFKB activating protein like Neighboring gene zinc finger and SCAN domain containing 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
NHGRI GWA Catalog

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein with KRAB and SCAN domains 4
Names
p373c6.1 (novel C2H2 type zinc finger protein)
zinc finger protein 307
zinc finger protein 427

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304506.2NP_001291435.1  zinc finger protein with KRAB and SCAN domains 4 isoform 2

    See identical proteins and their annotated locations for NP_001291435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK302017, AL022393
    UniProtKB/TrEMBL
    B7Z7H3
    Conserved Domains (6) summary
    smart00349
    Location:66126
    KRAB; krueppel associated box
    COG5048
    Location:219389
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:165187
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:69104
    KRAB; KRAB box
    pfam13465
    Location:235260
    zf-H2C2_2; Zinc-finger double domain
  2. NM_019110.5NP_061983.2  zinc finger protein with KRAB and SCAN domains 4 isoform 1

    See identical proteins and their annotated locations for NP_061983.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL022393, AY781778, HY070446
    Consensus CDS
    CCDS4647.1
    UniProtKB/Swiss-Prot
    Q969J2
    UniProtKB/TrEMBL
    A0A0S2Z658
    Related
    ENSP00000366509.2, ENST00000377294.3
    Conserved Domains (6) summary
    smart00431
    Location:49160
    SCAN; leucine rich region
    smart00349
    Location:221281
    KRAB; krueppel associated box
    COG5048
    Location:374544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:378398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320342
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:335357
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    28241697..28259258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249097.4XP_005249154.1  zinc finger protein with KRAB and SCAN domains 4 isoform X3

    See identical proteins and their annotated locations for XP_005249154.1

    Conserved Domains (5) summary
    smart00349
    Location:118178
    KRAB; krueppel associated box
    COG5048
    Location:271441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:275295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:217239
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:232254
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005249095.3XP_005249152.1  zinc finger protein with KRAB and SCAN domains 4 isoform X1

    See identical proteins and their annotated locations for XP_005249152.1

    UniProtKB/Swiss-Prot
    Q969J2
    UniProtKB/TrEMBL
    A0A0S2Z658
    Conserved Domains (6) summary
    smart00431
    Location:49160
    SCAN; leucine rich region
    smart00349
    Location:221281
    KRAB; krueppel associated box
    COG5048
    Location:374544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:378398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320342
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:335357
    zf-H2C2_2; Zinc-finger double domain
  3. XM_024446428.1XP_024302196.1  zinc finger protein with KRAB and SCAN domains 4 isoform X3

    Conserved Domains (5) summary
    smart00349
    Location:118178
    KRAB; krueppel associated box
    COG5048
    Location:271441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:275295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:217239
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:232254
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006715095.4XP_006715158.1  zinc finger protein with KRAB and SCAN domains 4 isoform X4

    See identical proteins and their annotated locations for XP_006715158.1

    Conserved Domains (6) summary
    smart00349
    Location:84144
    KRAB; krueppel associated box
    COG5048
    Location:237407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:241261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:183205
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:87122
    KRAB; KRAB box
    pfam13465
    Location:253278
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017010844.2XP_016866333.1  zinc finger protein with KRAB and SCAN domains 4 isoform X5

    UniProtKB/TrEMBL
    B7Z7H3
    Conserved Domains (6) summary
    smart00349
    Location:66126
    KRAB; krueppel associated box
    COG5048
    Location:219389
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:165187
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:69104
    KRAB; KRAB box
    pfam13465
    Location:235260
    zf-H2C2_2; Zinc-finger double domain
  6. XM_005249098.3XP_005249155.1  zinc finger protein with KRAB and SCAN domains 4 isoform X3

    See identical proteins and their annotated locations for XP_005249155.1

    Conserved Domains (5) summary
    smart00349
    Location:118178
    KRAB; krueppel associated box
    COG5048
    Location:271441
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:275295
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:217239
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:232254
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011514588.3XP_011512890.1  zinc finger protein with KRAB and SCAN domains 4 isoform X2

    Conserved Domains (8) summary
    smart00431
    Location:49131
    SCAN; leucine rich region
    smart00349
    Location:192252
    KRAB; krueppel associated box
    COG5048
    Location:345515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:349369
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:347369
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:195230
    KRAB; KRAB box
    pfam02023
    Location:49113
    SCAN; SCAN domain
    pfam13465
    Location:361386
    zf-H2C2_2; Zinc-finger double domain
  8. XM_011514589.2XP_011512891.1  zinc finger protein with KRAB and SCAN domains 4 isoform X5

    See identical proteins and their annotated locations for XP_011512891.1

    UniProtKB/TrEMBL
    B7Z7H3
    Conserved Domains (6) summary
    smart00349
    Location:66126
    KRAB; krueppel associated box
    COG5048
    Location:219389
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:165187
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:69104
    KRAB; KRAB box
    pfam13465
    Location:235260
    zf-H2C2_2; Zinc-finger double domain
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