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erbb2 erb-b2 receptor tyrosine kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 386966, updated on 16-Oct-2021

Summary

Official Symbol
erbb2provided by ZNC
Official Full Name
erb-b2 receptor tyrosine kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-031118-121
See related
Ensembl:ENSDARG00000026294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63601; wu:fv70f10
Orthologs
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Genomic context

See erbb2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (9360321..9438090, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (9322478..9400247, complement)
103 previous assembly Zv9 (GCF_000002035.4) 12 NC_007123.5 (10114523..10192292, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6b Neighboring gene post-GPI attachment to proteins phospholipase 3 Neighboring gene si:ch211-207i20.2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell migration involved in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination of anterior lateral line nerve axons IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination of posterior lateral line nerve axons IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within non-myelinated axon ensheathment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within posterior lateral line neuromast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
receptor tyrosine-protein kinase erbB-2
Names
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
NP_956413.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200119.2NP_956413.2  receptor tyrosine-protein kinase erbB-2 precursor

    See identical proteins and their annotated locations for NP_956413.2

    Status: PROVISIONAL

    Source sequence(s)
    AY914799
    UniProtKB/TrEMBL
    Q5EBY4
    Related
    ENSDARP00000010252.5, ENSDART00000003932.6
    Conserved Domains (7) summary
    smart00261
    Location:556599
    FU; Furin-like repeats
    cd00064
    Location:227267
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:705983
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:181335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:54167
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:713969
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:506636
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    9360321..9438090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394831.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    83972..161819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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