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MRGPRG MAS related GPR family member G [ Homo sapiens (human) ]

Gene ID: 386746, updated on 11-Apr-2024

Summary

Official Symbol
MRGPRGprovided by HGNC
Official Full Name
MAS related GPR family member Gprovided by HGNC
Primary source
HGNC:HGNC:24829
See related
Ensembl:ENSG00000182170 MIM:607234; AllianceGenome:HGNC:24829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRGG; GPR169
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See MRGPRG in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3217944..3218813, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3308916..3309785, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3239174..3240043, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3083786-3084412 Neighboring gene MPRA-validated peak1169 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3096337-3096837 Neighboring gene hESC enhancers GRCh37_chr11:3112372-3113180 and GRCh37_chr11:3113181-3113988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3114797-3115604 Neighboring gene oxysterol binding protein like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3075 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21160 Neighboring gene Sharpr-MPRA regulatory region 6583 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3156337-3156944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3156945-3157553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3157554-3158161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3170165-3170940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3170941-3171714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3171715-3172488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3174611-3175359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3178797-3179602 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:3180024-3180197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3184585-3185278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3187022-3187734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3193010-3193510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3193511-3194011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3203703-3204203 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3223199-3223854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3241139-3242101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:3245215-3246093 Neighboring gene MRGPRG antisense RNA 1 Neighboring gene MAS related GPR family member E Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3275868-3276509 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 8

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mas-related G-protein coupled receptor member G
Names
G protein-coupled receptor 169
G protein-coupled receptor MRGG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164377.1NP_001157849.1  mas-related G-protein coupled receptor member G

    See identical proteins and their annotated locations for NP_001157849.1

    Status: VALIDATED

    Source sequence(s)
    AC109309
    Consensus CDS
    CCDS44520.1
    UniProtKB/Swiss-Prot
    Q86SM5
    UniProtKB/TrEMBL
    W8W3J0
    Related
    ENSP00000330612.3, ENST00000332314.3
    Conserved Domains (1) summary
    PHA03087
    Location:13139
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    3217944..3218813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    3308916..3309785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)