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KRTAP10-3 keratin associated protein 10-3 [ Homo sapiens (human) ]

Gene ID: 386682, updated on 23-Nov-2021

Summary

Official Symbol
KRTAP10-3provided by HGNC
Official Full Name
keratin associated protein 10-3provided by HGNC
Primary source
HGNC:HGNC:22968
See related
Ensembl:ENSG00000212935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP10.3; KAP18-3; KAP18.3; KRTAP10.3; KRTAP18-3; KRTAP18.3
Summary
This gene encodes a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This gene encodes a member of the high sulfur KAP family. It is localized to a cluster of intronless KAPs at 21q22.3 which are located within the introns of the C21orf29 gene. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See KRTAP10-3 in Genome Data Viewer
Location:
21q22.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (44557790..44558795, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45977673..45978678, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene Sharpr-MPRA regulatory region 850 Neighboring gene keratin associated protein 10-2 Neighboring gene keratin associated protein 10-4 Neighboring gene keratin associated protein 10-5

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin-associated protein 10-3
Names
high sulfur keratin-associated protein 10.3
keratin-associated protein 18-3
keratin-associated protein 18.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050765.1 RefSeqGene

    Range
    4966..5971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198696.3NP_941969.2  keratin-associated protein 10-3

    See identical proteins and their annotated locations for NP_941969.2

    Status: REVIEWED

    Source sequence(s)
    AB076350, AJ566383, AP001067
    Consensus CDS
    CCDS42956.1
    UniProtKB/Swiss-Prot
    P60369
    Related
    ENSP00000375478.1, ENST00000391620.2
    Conserved Domains (2) summary
    pfam01500
    Location:78203
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:79123
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    44557790..44558795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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