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IL31 interleukin 31 [ Homo sapiens (human) ]

Gene ID: 386653, updated on 23-May-2018
Official Symbol
IL31provided by HGNC
Official Full Name
interleukin 31provided by HGNC
Primary source
See related
Ensembl:ENSG00000204671 MIM:609509; Vega:OTTHUMG00000168916
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
Low expression observed in reference dataset See more
See IL31 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (122172030..122174199, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122656577..122658746, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506691 Neighboring gene MLX interacting protein Neighboring gene leucine rich repeat containing 43 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Neighboring gene diablo IAP-binding mitochondrial protein Neighboring gene uncharacterized LOC101593348

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...


Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
cytokine activity IEA
Inferred from Electronic Annotation
more info
cytokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
immune system process IEA
Inferred from Electronic Annotation
more info
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
extracellular space IDA
Inferred from Direct Assay
more info

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014336.1NP_001014358.1  interleukin-31 precursor

    See identical proteins and their annotated locations for NP_001014358.1

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    ENSP00000366234.1, OTTHUMP00000239740, ENST00000377035.1, OTTHUMT00000401594
    Conserved Domains (1) summary
    IL31; Interleukin 31

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    122172030..122174199 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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