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KCTD4 potassium channel tetramerization domain containing 4 [ Homo sapiens (human) ]

Gene ID: 386618, updated on 9-Jun-2025
Official Symbol
KCTD4provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 4provided by HGNC
Primary source
HGNC:HGNC:23227
See related
Ensembl:ENSG00000180332 MIM:620638; AllianceGenome:HGNC:23227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA321C24.3
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in protein homooligomerization. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in brain (RPKM 6.1), skin (RPKM 1.4) and 1 other tissue See more
Orthologs
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See KCTD4 in Genome Data Viewer
Location:
13q14.12-q14.13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (45192853..45201045, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44412904..44421096, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45766988..45775180, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr13:45697873-45698066 Neighboring gene general transcription factor IIF subunit 2 Neighboring gene RN7SK pseudogene 4 Neighboring gene RNA, U6 small nuclear 69, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5311 Neighboring gene uncharacterized LOC124903168 Neighboring gene uncharacterized LOC105370190

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
BTB/POZ domain-containing protein KCTD4
Names
potassium channel tetramerisation domain containing 4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198404.3NP_940686.2  BTB/POZ domain-containing protein KCTD4

    See identical proteins and their annotated locations for NP_940686.2

    Status: VALIDATED

    Source sequence(s)
    AL138963, BC018063, BQ575935, DA683655, DB557284
    Consensus CDS
    CCDS9396.1
    UniProtKB/Swiss-Prot
    Q5W0P9, Q8WVF5
    Related
    ENSP00000368402.1, ENST00000379108.2
    Conserved Domains (1) summary
    cd18364
    Location:34119
    BTB_POZ_KCTD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    45192853..45201045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    44412904..44421096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)