KCTD4 potassium channel tetramerization domain containing 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KCTD4provided by HGNC
Official Full Name: potassium channel tetramerization domain containing 4provided by HGNC
Primary source: HGNC:HGNC:23227
See related: Ensembl:ENSG00000180332 MIM:620638; AllianceGenome:HGNC:23227
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: bA321C24.3
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in protein homooligomerization. [provided by Alliance of Genome Resources, Jun 2025]
Expression: Biased expression in brain (RPKM 6.1), skin (RPKM 1.4) and 1 other tissue See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13q14.12-q14.13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (45192853..45201045, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (44412904..44421096, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (45766988..45775180, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

A004S30 (e-PCR)
- UniSTS:17245

D13S1542 (e-PCR)
- UniSTS:473471

D13S1557 (e-PCR)
- UniSTS:473486

WI-13796 (e-PCR)
- UniSTS:63666

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: BTB/POZ domain-containing protein KCTD4

Names: potassium channel tetramerisation domain containing 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198404.3 → NP_940686.2 BTB/POZ domain-containing protein KCTD4

See identical proteins and their annotated locations for NP_940686.2

Status: VALIDATED

Source sequence(s)

AL138963, BC018063, BQ575935, DA683655, DB557284

Consensus CDS

CCDS9396.1

UniProtKB/Swiss-Prot

Q5W0P9, Q8WVF5

Related

ENSP00000368402.1, ENST00000379108.2

Conserved Domains (1) summary

cd18364
Location:34 → 119

BTB_POZ_KCTD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4)