Thoc6 THO complex 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thoc6provided by MGI
Official Full Name: THO complex 6provided by MGI
Primary source: MGI:MGI:2677480
See related: Ensembl:ENSMUSG00000041319 AllianceGenome:MGI:2677480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr58; F830014G06Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in several processes, including mRNA export from nucleus; negative regulation of apoptotic process; and viral mRNA export from host cell nucleus. Predicted to act upstream of or within RNA processing; apoptotic process; and mRNA transport. Predicted to be located in nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human THOC6 (THO complex 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 19.7), CNS E11.5 (RPKM 13.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 A3.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (23887592..23892891, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (23668618..23673917, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136026 (e-PCR)
- UniSTS:210022

C87282 (e-PCR)
- UniSTS:180968

Homology

Homologs of the Thoc6 gene: The Thoc6 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 393 organisms have orthologs with human gene Thoc6
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in viral mRNA export from host cell nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of THO complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of THO complex	ISO Inferred from Sequence Orthology more info
part_of THO complex part of transcription export complex	ISO Inferred from Sequence Orthology more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of transcription export complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: THO complex subunit 6 homolog

Names: WD repeat domain 58; WD repeat-containing protein 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008425.2 → NP_001008425.1 THO complex subunit 6 homolog

See identical proteins and their annotated locations for NP_001008425.1

Status: VALIDATED

Source sequence(s)

AC154766, AI850888, BC085131, CX224561

Consensus CDS

CCDS28454.1

UniProtKB/Swiss-Prot

Q5U4D9

UniProtKB/TrEMBL

A0A6P5NW81, A0A8C6MVT5

Related

ENSMUSP00000038137.5, ENSMUST00000047436.11

Conserved Domains (2) summary

sd00039
Location:28 → 74

7WD40; WD40 repeat [structural motif]

cl29593
Location:31 → 196

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001357380.1 → NP_001344309.1 THO complex subunit 6 homolog

Status: VALIDATED

Source sequence(s)

AC154766, AI850888, BC085131, CO428739

Consensus CDS

CCDS28454.1

UniProtKB/Swiss-Prot

Q5U4D9

UniProtKB/TrEMBL

A0A6P5NW81, A0A8C6MVT5

Related

ENSMUSP00000093239.5, ENSMUST00000095579.11

Conserved Domains (2) summary

sd00039
Location:28 → 74

7WD40; WD40 repeat [structural motif]

cl29593
Location:31 → 196

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

23887592..23892891 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249886.1 → XP_030105746.1 THO complex subunit 6 homolog isoform X1

UniProtKB/Swiss-Prot

Q5U4D9

UniProtKB/TrEMBL

A0A6P5NW81, A0A8C6MVT5

Related

ENSMUSP00000111153.3, ENSMUST00000115490.9

Conserved Domains (2) summary

sd00039
Location:28 → 74

7WD40; WD40 repeat [structural motif]

cl29593
Location:31 → 196

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...