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GDNF glial cell derived neurotrophic factor [ Bos taurus (domestic cattle) ]

Gene ID: 386587, updated on 30-Jan-2025
Official Symbol
GDNFprovided by VGNC
Official Full Name
glial cell derived neurotrophic factorprovided by VGNC
Primary source
VGNC:VGNC:29309
See related
BGD:BT21711; EnsemblRapid:ENSBTAG00070008566
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See GDNF in Genome Data Viewer
Location:
chromosome: 20
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (36614053..36642522)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132343235 Neighboring gene WD repeat domain 70 Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic Sequence:
NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Biological activity of cryopreserved bovine spermatogonial stem cells during in vitro culture. Oatley JM, et al. Biol Reprod, 2004 Sep. PMID 15151932
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glial cell-derived neurotrophic factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
glial cell line-derived neurotrophic factor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192849.1 → NP_001179778.1  glial cell line-derived neurotrophic factor precursor

    See identical proteins and their annotated locations for NP_001179778.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000020
    UniProtKB/TrEMBL
    A0AAA9TTY2
    Conserved Domains (1) summary
    pfam00019
    Location:118 → 210
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    36614053..36642522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005221582.5 → XP_005221639.1  glial cell line-derived neurotrophic factor isoform X1

    See identical proteins and their annotated locations for XP_005221639.1

    UniProtKB/TrEMBL
    A0AAA9TTY2
    Conserved Domains (1) summary
    pfam00019
    Location:118 → 210
    TGF_beta; Transforming growth factor beta like domain

  2. XM_005221583.5 → XP_005221640.1  glial cell line-derived neurotrophic factor isoform X2

    See identical proteins and their annotated locations for XP_005221640.1

    Conserved Domains (1) summary
    pfam00019
    Location:92 → 184
    TGF_beta; Transforming growth factor beta like domain

  3. XM_024981224.2 → XP_024836992.1  glial cell line-derived neurotrophic factor isoform X1

    UniProtKB/TrEMBL
    A0AAA9TTY2
    Related
    ENSBTAP00070011435.1, ENSBTAT00070019336.1
    Conserved Domains (1) summary
    pfam00019
    Location:118 → 210
    TGF_beta; Transforming growth factor beta like domain

  4. XM_059878674.1 → XP_059734657.1  glial cell line-derived neurotrophic factor isoform X2

  5. XM_024981225.2 → XP_024836993.1  glial cell line-derived neurotrophic factor isoform X3

    Conserved Domains (1) summary
    pfam00019
    Location:66 → 158
    TGF_beta; Transforming growth factor beta like domain

RNA

  1. XR_009491866.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials