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scny scrawny [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38648, updated on 5-Sep-2021

Summary

Official Symbol
scnyprovided by FlyBase
Official Full Name
scrawnyprovided by FlyBase
Primary source
FLYBASE:FBgn0260936
Locus tag
Dmel_CG5505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2331; anon-WO0118547.247; CG5505; Dmel\CG5505; dUsp36; dUSP36; et; l(3)02331; mule; Q9VRP5; Scny; usp36; Usp36; USP36
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Genomic context

See scny in Genome Data Viewer
Location:
64E8-64E7; 3-15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5769002..5776271)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5762102..5769371)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45831 Neighboring gene Thioredoxin-like Neighboring gene Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase Neighboring gene viriato Neighboring gene Myt1

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Lys63-specific deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol-dependent deubiquitinase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H2B conserved C-terminal lysine deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H2B conserved C-terminal lysine deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
scrawny
Names
CG5505-PB
CG5505-PC
CG5505-PD
CG5505-PG
CG5505-PH
CG5505-PI
CG5505-PJ
emperor's thumb
lethal (3) 02331
mule
scny-PB
scny-PC
scny-PD
scny-PG
scny-PH
scny-PI
scny-PJ
ubiquitin C-terminal hydrolase 36
ubiquitin specific protease 36
ubiquitin-specific protease 36
NP_001246639.1
NP_001246640.1
NP_647986.3
NP_729092.1
NP_729093.2
NP_729094.1
NP_729095.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5769002..5776271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168132.3NP_729092.1  scrawny, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729092.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRP5
    Related
    FBpp0076806, FBtr0077100
    Conserved Domains (3) summary
    pfam05279
    Location:617731
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd02661
    Location:171477
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:172477
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_001259710.2NP_001246639.1  scrawny, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246639.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRP5
    Related
    FBpp0300344, FBtr0307975
    Conserved Domains (3) summary
    pfam05279
    Location:617731
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd02661
    Location:171477
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:172477
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. NM_001259711.2NP_001246640.1  scrawny, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRP5
    Related
    FBpp0300345, FBtr0307976
    Conserved Domains (3) summary
    pfam05279
    Location:617731
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd02661
    Location:171477
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:172477
    UCH; Ubiquitin carboxyl-terminal hydrolase
  4. NM_139729.3NP_647986.3  scrawny, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647986.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRP5
    Related
    FBpp0303161, FBtr0330128
    Conserved Domains (3) summary
    pfam05279
    Location:547661
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd02661
    Location:101407
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:102407
    UCH; Ubiquitin carboxyl-terminal hydrolase
  5. NM_168135.2NP_729095.1  scrawny, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729095.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRP5
    Related
    FBpp0076807, FBtr0077101
    Conserved Domains (3) summary
    pfam05279
    Location:547661
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd02661
    Location:101407
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:102407
    UCH; Ubiquitin carboxyl-terminal hydrolase
  6. NM_168134.2NP_729094.1  scrawny, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRP5
    Related
    FBpp0076809, FBtr0077103
    Conserved Domains (3) summary
    pfam05279
    Location:527641
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd02661
    Location:81387
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:82387
    UCH; Ubiquitin carboxyl-terminal hydrolase
  7. NM_168133.2NP_729093.2  scrawny, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729093.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRP5
    Related
    FBpp0303160, FBtr0330127
    Conserved Domains (3) summary
    pfam05279
    Location:527641
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    cd02661
    Location:81387
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:82387
    UCH; Ubiquitin carboxyl-terminal hydrolase
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