Ir64a Ionotropic receptor 64a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ir64aprovided by FlyBase
Official Full Name: Ionotropic receptor 64aprovided by FlyBase
Primary source: FLYBASE:FBgn0035604
Locus tag: Dmel_CG10633
See related: AllianceGenome:FB:FBgn0035604
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 64a; CG10633; CT29782; DmelIR64a; Dmel\CG10633; DmIr64a; Ir64; ir64a; IR64a; IR64A
Summary: Contributes to extracellular ligand-gated monoatomic ion channel activity and olfactory receptor activity. Involved in several processes, including cellular response to acetate; cellular response to acidic pH; and olfactory behavior. Located in dendrite membrane and sensory dendrite. Is expressed in adult olfactory antennal lobe glomerulus; adult olfactory receptor neuron Ir64a; and antennal segment 3 sense organ. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5378786..5382821, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5371886..5375921, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to extracellular ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	ISM Inferred from Sequence Model more info	PubMed
contributes_to olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to acetate	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to acetate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to chlorate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sensory dendrite	IDA Inferred from Direct Assay more info	PubMed

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