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KRT13 keratin 13 [ Homo sapiens (human) ]

Gene ID: 3860, updated on 5-Jul-2020

Summary

Official Symbol
KRT13provided by HGNC
Official Full Name
keratin 13provided by HGNC
Primary source
HGNC:HGNC:6415
See related
Ensembl:ENSG00000171401 MIM:148065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K13; CK13; WSN2
Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward esophagus (RPKM 15373.8) See more
Orthologs

Genomic context

See KRT13 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41500981..41505612, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39657233..39661865, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 35 Neighboring gene keratin 36 Neighboring gene keratin 15 Neighboring gene microRNA 6510 Neighboring gene keratin 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3781, MGC161462

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
keratin filament IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 13
Names
CK-13
cytokeratin 13
keratin 13, type I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008406.1 RefSeqGene

    Range
    5001..9633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002274.4NP_002265.3  keratin, type I cytoskeletal 13 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) utilizes an alternate splice site in the 3' coding region, which results in a frameshift and early stop codon, compared to transcript variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC019349
    Consensus CDS
    CCDS11397.1
    Related
    ENSP00000336604.3, ENST00000336861.7
  2. NM_153490.3NP_705694.3  keratin, type I cytoskeletal 13 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC019349
    Consensus CDS
    CCDS11396.1
    Related
    ENSP00000246635.3, ENST00000246635.8
    Conserved Domains (1) summary
    pfam00038
    Location:103415
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41500981..41505612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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